Document Detail


Multifunctional nanorods for biomedical applications.
MedLine Citation:
PMID:  17684708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Multifunctional nanorods have shown significant potential in a wide range of biomedical applications. Nanorods can be synthesized by a top down or bottom-up approach. The bottom-up approach commonly utilizes a template deposition methodology. A variety of metal segments can easily be incorporated into the nanorods. This permits high degrees of chemical and dimensional control. High aspect-ratio nanorods have a large surface area for functionalization. By varying the metal segments in the nanorods, spatial control over the binding of functional biomolecules that correspond with the unique surface chemistry of the metal segment can be achieved. Functionalized multicomponent nanorods are utilized in applications ranging from multiplexing, protein sensing, glucose sensing, imaging, biomolecule-associated nanocircuits, gene delivery and vaccinations.
Authors:
Megan E Pearce; Jessica B Melanko; Aliasger K Salem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2007-08-08
Journal Detail:
Title:  Pharmaceutical research     Volume:  24     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2335-52     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, College of Engineering, University of Iowa, Iowa City, Iowa 52242, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomedical Technology*
Biosensing Techniques
Blood Glucose / analysis
Diagnostic Imaging / methods
Gene Transfer Techniques
Humans
Metal Nanoparticles / chemistry*
Nanotechnology*
Nanotubes / chemistry*
Proteins / analysis
Technology, Pharmaceutical / methods*
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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