| Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. | |
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MedLine Citation:
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PMID: 20828811 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stable and tumor-targeting multifunctional wormlike polymer vesicles simultaneously loaded with superparamagnetic iron oxide (SPIO) nanoparticles (NPs) as magnetic resonance imaging (MRI) contrast agent and anticancer drug doxorubicin (DOX) were developed for targeted cancer therapy and ultrasensitive MR imaging. These multifunctional wormlike polymer vesicles were formed by heterobifunctional amphiphilic triblock copolymers R (R = methoxy or folate (FA))-PEG(114)-PLA(x)-PEG(46)-acrylate using a double emulsion method. The long PEG segments bearing methoxy/folate groups (CH(3)O/FA-PEG(114)) were mostly segregated to the outer hydrophilic PEG layers of the wormlike vesicles thereby providing active tumor-targeting ability, while the short PEG segments bearing acrylate groups (PEG(46)-acrylate) were mostly segregated onto the inner hydrophilic PEG layers of the wormlike vesicles thereby allowing the inner PEG layers to be crosslinked via free radical polymerization for enhanced in vivo stability. The hydrophobic anticancer drug, DOX, was loaded into the hydrophobic membrane of the wormlike vesicles. Meanwhile, a cluster of hydrophilic SPIO NPs was encapsulated into the aqueous cores of the stable wormlike vesicles with crosslinked inner PEG layers for ultrasensitive MRI detection. Cellular uptake of the FA-conjugated wormlike vesicles facilitated by the folate receptor-mediated endocytosis process was higher than that of the FA-free vesicles thereby leading to high cytotoxicity against the HeLa human cervical tumor cell line. Moreover, the SPIO/DOX-loaded wormlike vesicles with crosslinked inner PEG layers demonstrated a much higher r(2) relaxivity value than Feridex, a commercially available T(2) agent, which can be attributed to the high SPIO NPs loading level as well as the SPIO clustering effect. These unique stable and tumor-targeting multifunctional SPIO/DOX-loaded wormlike polymer vesicles would make targeted cancer theranostics possible thereby paving the road for personalized medicine. |
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Authors:
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Xiaoqiang Yang; Jamison J Grailer; Ian J Rowland; Alireza Javadi; Samuel A Hurley; Douglas A Steeber; Shaoqin Gong |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-09 |
Journal Detail:
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Title: Biomaterials Volume: 31 ISSN: 1878-5905 ISO Abbreviation: Biomaterials Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8100316 Medline TA: Biomaterials Country: England |
Other Details:
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Languages: eng Pagination: 9065-73 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Mechanical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Death
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drug effects Dextrans / chemistry* Doxorubicin / pharmacology, therapeutic use* Drug Carriers / chemistry* Drug Delivery Systems Flow Cytometry Folic Acid / pharmacology Hela Cells Humans Hydrophobic and Hydrophilic Interactions / drug effects Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy Magnetite Nanoparticles / chemistry* Microscopy, Confocal Nanoparticles / ultrastructure Neoplasms / drug therapy* Polymers / chemical synthesis, chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Drug Carriers; 0/Magnetite Nanoparticles; 0/Polymers; 119683-68-0/ferumoxides; 23214-92-8/Doxorubicin; 59-30-3/Folic Acid; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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