Document Detail

Multifunctional magnetic-optical nanoparticle probes for simultaneous detection, separation, and thermal ablation of multiple pathogens.
MedLine Citation:
PMID:  19943255     Owner:  NLM     Status:  MEDLINE    
Multifunctional nanoparticles possessing magnetization and near-infrared (NIR) absorption have warranted interest due to their significant applications in magnetic resonance imaging, diagnosis, bioseparation, target delivery, and NIR photothermal ablation. Herein, the site-selective assembly of magnetic nanoparticles onto the ends or ends and sides of gold nanorods with different aspect ratios (ARs) to create multifunctional nanorods decorated with varying numbers of magnetic particles is described for the first time. The resulting hybrid nanoparticles are designated as Fe(3)O(4)-Au(rod)-Fe(3)O(4) nanodumbbells and Fe(3)O(4)-Au(rod) necklacelike constructs with tunable optical and magnetic properties, respectively. These hybrid nanomaterials can be used for multiplex detection and separation because of their tunable magnetic and plasmonic functionality. More specifically, Fe(3)O(4)-Au(rod) necklacelike probes of different ARs are utilized for simultaneous optical detection based on their plasmon properties, magnetic separation, and photokilling of multiple pathogens from a single sample at one time. The combined functionalities of the synthesized probes will open up many exciting opportunities in dual imaging for targeted delivery and photothermal therapy.
Chungang Wang; Joseph Irudayaraj
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Small (Weinheim an der Bergstrasse, Germany)     Volume:  6     ISSN:  1613-6829     ISO Abbreviation:  Small     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-20     Completed Date:  2010-03-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235338     Medline TA:  Small     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  283-9     Citation Subset:  IM    
ABE Building, Birck Nanotechnology Center and Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.
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MeSH Terms
Ablation Techniques / methods*
Bacteria / isolation & purification*,  ultrastructure
Ferric Compounds / chemistry
Gold / chemistry
Molecular Probes / chemistry*
Nanoparticles / chemistry*,  ultrastructure
Nanotubes / ultrastructure
Optical Phenomena*
Spectrophotometry, Ultraviolet
Spectroscopy, Near-Infrared
Reg. No./Substance:
0/Ferric Compounds; 0/Molecular Probes; 1309-37-1/ferric oxide; 7440-57-5/Gold

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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