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Multifunctional Core-Shell Upconverting Nanoparticles for Imaging and Photodynamic Therapy of Liver Cancer Cells.
MedLine Citation:
PMID:  22279027     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Lanthanide-doped upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica-coated NaGdF(4) :Yb,Er/NaGdF(4) nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC(4) Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. These UCNP@SiO(2) (AlC(4) Pc) nanoparticles were uniform in size, stable against photosensitizer leaching, and highly efficient in photogenerating cytotoxic singlet oxygen under near-infrared (NIR) light. In vitro studies indicated that these nanoparticles could effectively kill cancer cells upon NIR irradiation. Moreover, the nanoparticles also demonstrated good MR contrast, both in aqueous solution and inside cells. This is the first time that NaGdF(4) :Yb,Er/NaGdF(4) upconversion-nanocrystal-based multifunctional nanomaterials have been synthesized and applied in PDT. Our results show that these multifunctional nanoparticles are very promising for applications in versatile imaging diagnosis and as a therapy tool in biomedical engineering.
Authors:
Zengxia Zhao; Yuning Han; Chenghong Lin; Dong Hu; Fang Wang; Xiaolan Chen; Zhong Chen; Nanfeng Zheng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  Chemistry, an Asian journal     Volume:  -     ISSN:  1861-471X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101294643     Medline TA:  Chem Asian J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
State Key Laboratory for Physical Chemistry of Solid, Surfaces and the Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005 (P.R. China), Fax: (+86) 592-2183047.
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