Document Detail


Multifunctional, biocompatible supramolecular hydrogelators consist only of nucleobase, amino acid, and glycoside.
MedLine Citation:
PMID:  21928792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The integration of nucleobase, amino acid, and glycoside into a single molecule results in a novel class of supramolecular hydrogelators, which not only exhibit biocompatibility and biostability but also facilitate the entry of nucleic acids into cytosol and nuclei of cells. This work illustrates a simple way to generate an unprecedented molecular architecture from the basic biological building blocks for the development of sophisticated soft nanomaterials, including supramolecular hydrogels.
Authors:
Xinming Li; Yi Kuang; Junfeng Shi; Yuan Gao; Hsin-Chieh Lin; Bing Xu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-10-07
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  133     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-26     Completed Date:  2012-02-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17513-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / chemistry*
Biocompatible Materials / chemical synthesis,  chemistry*
Cell Survival
Drug Carriers / chemical synthesis,  chemistry
Glycosides / chemistry*
HeLa Cells
Humans
Hydrogels / chemical synthesis,  chemistry*
Macromolecular Substances / chemical synthesis,  chemistry
Nucleotides / chemistry*
Grant Support
ID/Acronym/Agency:
R01 CA142746/CA/NCI NIH HHS; R01 CA142746-02/CA/NCI NIH HHS; R01CA142746/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Biocompatible Materials; 0/Drug Carriers; 0/Glycosides; 0/Hydrogels; 0/Macromolecular Substances; 0/Nucleotides
Comments/Corrections

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