Document Detail

Multifocal visual evoked potential latency analysis: predicting progression to multiple sclerosis.
MedLine Citation:
PMID:  16769865     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To monitor the difference in conversion rates to multiple sclerosis (MS) in 46 patients with optic neuritis between patients with multifocal visual evoked potential latency delay and those with normal latency. DESIGN: Prospective case series. SETTING: Metropolitan neuro-ophthalmology clinic. PARTICIPANTS: Forty-six patients with optic neuritis who did not have a diagnosis of MS on enrollment in the study. MAIN OUTCOME MEASURES: Conversion to MS according to the McDonald criteria. RESULTS: Analysis revealed that only 22 subjects had multifocal visual evoked potential latency delay. Over 1 year, 36.4% of patients with optic neuritis with latency delays progressed clinically to MS compared with 0% of those with normal latencies (P = .03, chi2). CONCLUSION: This may indicate that multifocal visual evoked potential latency delay can assist in predicting progression to future MS.
Clare Fraser; Alexander Klistorner; Stuart Graham; Raymond Garrick; Francis Billson; John Grigg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  63     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  847-50     Citation Subset:  AIM; IM    
Save Sight Institute, Sydney, NSW, Australia.
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MeSH Terms
Analysis of Variance
Evoked Potentials, Visual / physiology*
Multiple Sclerosis / complications,  physiopathology*
Optic Neuritis / complications,  physiopathology*
Pattern Recognition, Visual / physiology
Photic Stimulation / methods
Prospective Studies
Reaction Time / physiology*

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