Document Detail

Multifocal hypointense cerebral lesions on gradient-echo MR are associated with chronic hypertension.
MedLine Citation:
PMID:  8933864     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the basis for multifocal hypointense lesions within the brain as identified on T2*-weighted gradient-echo MR imaging in patients with no known or presumed cause of these lesions. METHODS: In the first of a two-part study design, we retrospectively reviewed a case series of 38 patients whose gradient-echo MR images showed multiple hypointense lesions within the brain parenchyma. Thirty-one cases in which the cause was known or presumed (eg, head trauma or cavernous angioma) were excluded from further review. The MR studies and clinical findings of the remaining seven cases were reexamined. In the second part, using a cohort study design with respect to hypertension, we prospectively reviewed the gradient-echo images from MR studies of 65 patients and control subjects enrolled in two ongoing clinical studies, one on "possible vascular dementia" (n = 33) and the other on "possible motor neuron disorder" (n = 32). RESULTS: In the first part of the study, we found seven cases with a pattern of multiple hypointense lesions involving the deep gray matter nuclei, especially the basal ganglia (n = 6) and thalamus (n = 5). In addition, involvement of the corona radiata (n = 5), brain stem (n = 4), and cerebellum (n = 3) was seen. Clinical review revealed a history of chronic hypertension in all seven patients. In the cohort study, we found three of 65 persons who had two or more focal hypointense lesions that involved the basal ganglia or thalami. Review of the clinical data showed that all three patients were being treated for hypertension; also, all three were patients from the "possible vascular dementia" group. CONCLUSIONS: The MR imaging pattern of multifocal hypointense lesions within the basal ganglia, thalamus, and other deep cerebral structures is more commonly found among patients with a history of chronic hypertension than in patients without chronic hypertension.
S Chan; K Kartha; S S Yoon; D W Desmond; S K Hilal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  17     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-02-26     Completed Date:  1997-02-26     Revised Date:  2008-02-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1821-7     Citation Subset:  IM    
Department of Radiology, Neurological Institute of New York, NY, USA.
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MeSH Terms
Aged, 80 and over
Basal Ganglia / pathology
Brain / pathology*
Chronic Disease
Cohort Studies
Dementia, Vascular / pathology
Hypertension / complications,  pathology*
Magnetic Resonance Imaging*
Middle Aged
Motor Neuron Disease / pathology
Prospective Studies
Retrospective Studies
Thalamus / pathology
Grant Support

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