Document Detail


Multifocal chorioretinal lesions in Borzoi dogs.
MedLine Citation:
PMID:  16178845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To identify the prevalence of Borzoi chorioretinopathy in western Canada, characterize lesions with fluorescein angiography, determine if lesions were progressive, clarify the association of progressive retinal atrophy and investigate the etiology. MATERIALS AND METHODS: Serial ophthalmic examination, fundus photography, electroretinography, and fluorescein angiography were used to evaluate Borzoi dogs with lesions of Borzoi chorioretinopathy. Pedigree analysis and test breeding of two affected dogs were completed to determine the heritability of Borzoi chorioretinopathy. RESULTS: One hundred three Borzoi dogs were examined between 1998 and 2003. Focal, peripheral, tapetal, hyper-reflective and pigmented areas consistent with focal retinal degeneration and RPE pigmentation were identified in 12 dogs between 7 months and 7 years of age. Seven males and five female dogs were affected. Ophthalmoscopy and fundus photography over 5 years revealed individual lesions that did not progress or coalesce in 12 affected dogs. Electroretinography of affected and normal Borzoi dogs confirmed that retinal function was similar in normal and affected dogs up to 7 years of age. Fluorescein angiography was performed in three affected dogs and confirmed intact blood-ocular barriers, focal retinal pigment epithelium hypertrophy, and focal absence of choroiocapillaris corresponding to chronic, focal lesions. Pedigree analysis precluded simple dominant, X-linked dominant, or X-linked recessive inheritance. One male dog from the test-bred litter developed bilateral lesions at 14 months of age. Simple recessive, polygenetic, and acquired etiologies of these lesions cannot be ruled out at this time. CONCLUSIONS: Borzoi chorioretinopathy is an acquired condition that initially manifests as focal retinal edema and loss of choriocapillaris and tapetum. With time the retina degenerates becoming hyper-reflective and with RPE hyper-pigmentation and clumping within the borders of the tapetal lesions. Choriocapillaris remains hypofluorescent on fluorescein angiography. Progressive retinal atrophy was excluded as an etiology of multifocal chorioretinopathy in Borzois dogs. This condition is not inherited by simple autosomal dominant or sex-linked modes of inheritance.
Authors:
Eric S Storey; Bruce H Grahn; Jane Alcorn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary ophthalmology     Volume:  8     ISSN:  1463-5216     ISO Abbreviation:  Vet Ophthalmol     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-09-23     Completed Date:  2006-01-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100887377     Medline TA:  Vet Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-47     Citation Subset:  IM    
Affiliation:
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine. storeye@vetmed.lsu.edu
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / epidemiology,  genetics,  pathology,  veterinary
Animals
Breeding
Choroid Diseases / epidemiology,  genetics,  pathology,  veterinary*
Disease Progression
Dog Diseases / epidemiology*,  genetics*,  pathology
Dogs
Electroretinography / veterinary
Female
Fluorescein Angiography / veterinary
Fundus Oculi
Genetic Predisposition to Disease
Male
Optic Atrophy / veterinary
Pedigree
Prevalence
Retina / pathology
Retinal Diseases / epidemiology,  genetics,  pathology,  veterinary*
Saskatchewan / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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