Document Detail


Multifocal VZV vasculopathy with temporal artery infection mimics giant cell arteritis.
MedLine Citation:
PMID:  23635966     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To address the incidence of varicella-zoster virus (VZV) infection in patients with biopsy-negative giant cell arteritis (GCA), we examined archived biopsy-negative temporal arteries from subjects with clinically suspected GCA for the presence of VZV antigen.
METHODS: Formalin-fixed, paraffin-embedded temporal arteries that were pathologically negative for GCA and normal temporal arteries were analyzed immunohistochemically for VZV and herpes simplex virus-1 (HSV-1) antigen.
RESULTS: Five (21%) of 24 temporal arteries from patients who were clinically suspect but biopsy negative for GCA revealed VZV but not HSV-1 by immunohistochemical analysis. Thirteen normal temporal arteries did not contain VZV or HSV-1 antigen. All 5 subjects whose temporal arteries contained VZV antigen presented with clinical and laboratory features of GCA and early visual disturbances.
CONCLUSION: Multifocal VZV vasculopathy can present with the full spectrum of clinical features and laboratory abnormalities characteristically seen in GCA.
Authors:
Maria A Nagel; Jeffrey L Bennett; Nelly Khmeleva; Alexander Choe; April Rempel; Philip J Boyer; Don Gilden
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-05-01
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-28     Completed Date:  2013-07-26     Revised Date:  2014-09-30    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2017-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Diagnosis, Differential
Female
Giant Cell Arteritis / diagnosis,  pathology*,  virology*
Herpes Zoster / diagnosis*,  epidemiology,  pathology
Herpesvirus 3, Human / pathogenicity*
Humans
Incidence
Inflammation / diagnosis,  pathology,  virology
Male
Middle Aged
Temporal Arteries / pathology*,  virology*
Vascular Diseases / diagnosis,  pathology*,  virology*
Grant Support
ID/Acronym/Agency:
AG006127/AG/NIA NIH HHS; AG032958/AG/NIA NIH HHS; K08 NS067070/NS/NINDS NIH HHS; NS067070/NS/NINDS NIH HHS; P01 AG032958/AG/NIA NIH HHS; R01 AG006127/AG/NIA NIH HHS; R25 GM-083333/GM/NIGMS NIH HHS
Comments/Corrections
Comment In:
Surv Ophthalmol. 2014 Sep-Oct;59(5):574-5   [PMID:  24656437 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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