Document Detail


Multifarious roles of sialic acids in immunity.
MedLine Citation:
PMID:  22524423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of vertebrates and so-called "higher" invertebrates, and on certain bacteria that interact with vertebrates. This overview surveys examples of biological roles of sialic acids in immunity, with emphasis on an evolutionary perspective. Given the breadth of the subject, the treatment of individual topics is brief. Subjects discussed include biophysical effects regulation of factor H; modulation of leukocyte trafficking via selectins; Siglecs in immune cell activation; sialic acids as ligands for microbes; impact of microbial and endogenous sialidases on immune cell responses; pathogen molecular mimicry of host sialic acids; Siglec recognition of sialylated pathogens; bacteriophage recognition of microbial sialic acids; polysialic acid modulation of immune cells; sialic acids as pathogen decoys or biological masks; modulation of immunity by sialic acid O-acetylation; sialic acids as antigens and xeno-autoantigens; antisialoglycan antibodies in reproductive incompatibility; and sialic-acid-based blood groups.
Authors:
Ajit Varki; Pascal Gagneux
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1253     ISSN:  1749-6632     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-06-28     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-36     Citation Subset:  IM    
Copyright Information:
© 2012 New York Academy of Sciences.
Affiliation:
Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, 92093-0687, USA. a1varki@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biophysical Phenomena
Host-Pathogen Interactions / immunology
Humans
Immunity, Innate
Lectins / immunology
Leukocytes / immunology
Ligands
Microbiological Phenomena
Models, Immunological
Molecular Mimicry / immunology
Neuraminidase / immunology
Selectins / chemistry,  immunology
Sialic Acid Binding Immunoglobulin-like Lectins
Sialic Acids / chemistry,  immunology*
Grant Support
ID/Acronym/Agency:
P01 HL107150/HL/NHLBI NIH HHS; R01 CA038701/CA/NCI NIH HHS; R01 GM032373/GM/NIGMS NIH HHS; R01 GM032373-29/GM/NIGMS NIH HHS; R01 GM095882/GM/NIGMS NIH HHS; R01 GM095882-01A1/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Lectins; 0/Ligands; 0/Selectins; 0/Sialic Acid Binding Immunoglobulin-like Lectins; 0/Sialic Acids; EC 3.2.1.18/Neuraminidase
Comments/Corrections

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