Document Detail

Multifactorial mediation of post norepinephrine induced intestinal hyperemia.
MedLine Citation:
PMID:  7949234     Owner:  NLM     Status:  MEDLINE    
We evaluated several potential endogenous mediators of post norepinephrine induced hyperemia in the mesenteric circulation. Hyperemia was elicited in the anesthetized rat anterior mesenteric artery after cessation of intravenous norepinephrine infusion at 0.125 to 1.0 x 10(-8) M/min x 4 min. Arterial blood pressure was measured with a transducer, and the velocity of arterial blood flow was determined with pulsed Doppler velocimetry. Conductance at the height of mesenteric hyperemia, the post norepinephrine hyperemia volume, and the autoregulatory escape volume were calculated from recorded measurements. The higher doses of norepinephrine increased both the hyperemia volume and peak conductance in both control and capsaicin pretreated rats. Hyperemic parameters were significantly diminished by pretreatment with either yohimbine, propranolol, adenosine deaminase, or methylene blue. Combining adenosine deaminase with propranolol further reduced peak conductance and the hyperemia volume compared with enzyme pretreatment alone. The magnitude of hyperemia was related to the escape volume but not to the extent of norepinephrine induced vasoconstriction. We conclude that post norepinephrine induced hyperemia in the rat mesenteric circulation is modulated by alpha 2 and beta 2 adrenergic receptor activation, adenosine release, and endothelial factors.
G Remak; O D Hottenstein; E D Jacobson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  45     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  241-57     Citation Subset:  IM    
Department of Medicine, University of Colorado School of Medicine, Denver.
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MeSH Terms
Adenosine Deaminase / pharmacology
Animals, Newborn
Capsaicin / pharmacology
Dose-Response Relationship, Drug
Hexamethonium Compounds / pharmacology
Hyperemia / chemically induced*
Intestines / blood supply*,  drug effects
Lidocaine / pharmacology
Methylene Blue / pharmacology
Neurons, Afferent / drug effects,  metabolism
Norepinephrine / pharmacology
Propranolol / pharmacology
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-2 / antagonists & inhibitors,  drug effects
Receptors, Adrenergic, beta-2 / antagonists & inhibitors,  drug effects
Splanchnic Circulation / drug effects
Sympathetic Nervous System / drug effects,  metabolism
Grant Support
Reg. No./Substance:
0/Hexamethonium Compounds; 0/Receptors, Adrenergic, alpha-2; 0/Receptors, Adrenergic, beta-2; 137-58-6/Lidocaine; 404-86-4/Capsaicin; 51-41-2/Norepinephrine; 525-66-6/Propranolol; 61-73-4/Methylene Blue; EC Deaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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