Document Detail


Multifactorial QT interval prolongation.
MedLine Citation:
PMID:  20544619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acquired long QT interval has been widely reported to be a consequence of drug therapy and electrolyte disturbances. We describe two cases of multifactorial acquired QT interval prolongation and torsades de pointes. In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia. In the second case, QT interval prolongation occurred in a patient taking quetiapine and citalopram, and whose use of hydrocholorothiazide and history of chronic alcohol abuse likely contributed by rendering the patient hypokalemic. These cases highlight the potential risks associated with polypharmacy and demonstrate that though torsades de pointes is an uncommon arrhythmia, the combination of multiple factors known to prolong QT interval may precipitate this life-threatening arrhythmia.
Authors:
Geneviève Digby; Jimmy Machaalany; Paul Malik; Michelle Methot; Christopher S Simpson; Damian Redfearn; Adrian Baranchuk
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cardiology journal     Volume:  17     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / complications
Amiodarone / adverse effects
Antipsychotic Agents / adverse effects
Arrhythmias, Cardiac / blood,  etiology*,  physiopathology,  therapy
Biological Markers / blood
Citalopram / adverse effects
Cyclohexanols / adverse effects
Dibenzothiazepines / adverse effects
Diuretics / adverse effects
Domperidone / adverse effects
Dopamine Antagonists / adverse effects
Electrocardiography
Female
Humans
Hydrochlorothiazide / adverse effects
Hypokalemia / complications
Magnesium / blood
Middle Aged
Polypharmacy
Risk Factors
Serotonin Uptake Inhibitors / adverse effects
Torsades de Pointes / blood,  etiology*,  physiopathology,  therapy
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Biological Markers; 0/Cyclohexanols; 0/Dibenzothiazepines; 0/Diuretics; 0/Dopamine Antagonists; 0/Serotonin Uptake Inhibitors; 0/quetiapine; 1951-25-3/Amiodarone; 57808-66-9/Domperidone; 58-93-5/Hydrochlorothiazide; 59729-33-8/Citalopram; 7439-95-4/Magnesium; 93413-69-5/venlafaxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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