| Multifactorial QT interval prolongation. | |
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MedLine Citation:
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PMID: 20544619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acquired long QT interval has been widely reported to be a consequence of drug therapy and electrolyte disturbances. We describe two cases of multifactorial acquired QT interval prolongation and torsades de pointes. In the first case, the drugs venlafaxine, amiodarone and domperidone may have contributed to QT interval prolongation in a patient with hypokalemia and hypomagnesaemia. In the second case, QT interval prolongation occurred in a patient taking quetiapine and citalopram, and whose use of hydrocholorothiazide and history of chronic alcohol abuse likely contributed by rendering the patient hypokalemic. These cases highlight the potential risks associated with polypharmacy and demonstrate that though torsades de pointes is an uncommon arrhythmia, the combination of multiple factors known to prolong QT interval may precipitate this life-threatening arrhythmia. |
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Authors:
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Geneviève Digby; Jimmy Machaalany; Paul Malik; Michelle Methot; Christopher S Simpson; Damian Redfearn; Adrian Baranchuk |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cardiology journal Volume: 17 ISSN: 1897-5593 ISO Abbreviation: Cardiol J Publication Date: 2010 |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101392712 Medline TA: Cardiol J Country: Poland |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Kingston General Hospital, Queen's University, Kingston, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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complications Amiodarone / adverse effects Antipsychotic Agents / adverse effects Arrhythmias, Cardiac / blood, etiology*, physiopathology, therapy Biological Markers / blood Citalopram / adverse effects Cyclohexanols / adverse effects Dibenzothiazepines / adverse effects Diuretics / adverse effects Domperidone / adverse effects Dopamine Antagonists / adverse effects Electrocardiography Female Humans Hydrochlorothiazide / adverse effects Hypokalemia / complications Magnesium / blood Middle Aged Polypharmacy Risk Factors Serotonin Uptake Inhibitors / adverse effects Torsades de Pointes / blood, etiology*, physiopathology, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Biological Markers; 0/Cyclohexanols; 0/Dibenzothiazepines; 0/Diuretics; 0/Dopamine Antagonists; 0/Serotonin Uptake Inhibitors; 0/quetiapine; 1951-25-3/Amiodarone; 57808-66-9/Domperidone; 58-93-5/Hydrochlorothiazide; 59729-33-8/Citalopram; 7439-95-4/Magnesium; 93413-69-5/venlafaxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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