Document Detail


Multifaceted approach to the diagnosis and classification of acute leukemias.
MedLine Citation:
PMID:  10926919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until recently, the diagnosis and classification of acute myeloid (AML) and acute lymphoblastic (ALL) leukemias was based almost exclusively on well-defined morphologic criteria and cytochemical stains. Although most cases can be diagnosed by these methods, there is only modest correlation between morphologic categories and treatment responsiveness and prognosis. The expansion of therapeutic options and improvement in remission induction and disease-free survival for both AML and ALL have stimulated emphasis on defining good and poor treatment response groups. This is most effectively accomplished by a multifaceted approach to diagnosis and classification using immunophenotyping, cytogenetics, and molecular analysis in addition to the traditional methods. Immunophenotyping is important in characterizing morphologically poorly differentiated acute leukemias and in defining prognostic categories of ALL. Cytogenetic and molecular studies provide important prognostic information and are becoming vitally important in determining the appropriate treatment protocol. With optimal application of these techniques in the diagnosis of acute leukemias, treatment strategies can be more specifically directed and new therapeutic approaches can be evaluated more effectively.
Authors:
R W McKenna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical chemistry     Volume:  46     ISSN:  0009-9147     ISO Abbreviation:  Clin. Chem.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-22     Completed Date:  2000-08-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421549     Medline TA:  Clin Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1252-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9072, USA. rmcken@mednet.swmed.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Histocytochemistry
Humans
Immunophenotyping
Karyotyping
Leukemia, Myeloid / classification*,  diagnosis*,  genetics,  pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / classification*,  diagnosis*,  genetics,  pathology
World Health Organization

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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