| Multidrug transporters and antibiotic resistance in Lactococcus lactis. | |
| | |
MedLine Citation:
|
PMID: 12206883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The Gram-positive bacterium Lactococcus lactis produces two distinct multidrug transporters, designated LmrA and LmrP, that both confer resistance to a wide variety of cationic lipophilic cytotoxic compounds as well as to many clinically relevant antibiotics. While LmrP is a proton/drug antiporter that belongs to the major facilitator superfamily of secondary transporters, LmrA is an ATP-dependent primary transporter that belongs to the ATP-binding cassette superfamily of transport proteins. Both LmrA and LmrP function as "hydrophobic vacuum cleaners" by excreting lipophilic cationic compounds from the inner leaflet of the membrane directly into the external water phase. LmrA is both functionally and structurally homologous to the human multidrug transporter P-glycoprotein. LmrA is a half ABC transporter that is functional as a homodimer, consistent with the general four-domain organization of ABC transporters, and is proposed to mediate drug transport by an alternating two-site transport mechanism. |
| | |
Authors:
|
Gerrit J Poelarends; Piotr Mazurkiewicz; Wil N Konings |
Related Documents
:
|
12180533 - Characterization of mefenamic acid-guaiacol ester: stability and transport across caco-... 12538813 - Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interact... 17116023 - Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction prof... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Biochimica et biophysica acta Volume: 1555 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-09-03 Completed Date: 2002-10-18 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
|
Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
ATP-Binding Cassette Transporters
/
chemistry*,
genetics,
metabolism Bacterial Proteins / chemistry*, genetics, metabolism Cytoplasm / metabolism Drug Resistance Intracellular Membranes / chemistry, metabolism Lactococcus lactis / chemistry, genetics, metabolism* Lipid Bilayers / chemistry Membrane Transport Proteins / chemistry*, genetics, metabolism Models, Molecular Multidrug Resistance-Associated Proteins* |
| Chemical | |
Reg. No./Substance:
|
0/ATP-Binding Cassette Transporters; 0/Bacterial Proteins; 0/Lipid Bilayers; 0/LmrA protein, Lactococcus lactis; 0/LmrP protein, Lactococcus lactis; 0/Membrane Transport Proteins; 0/Multidrug Resistance-Associated Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiherpes simplex virus type 2 activity of casuarinin from the bark of Terminalia arjuna Linn.
Next Document: A conformational change in the isolated NADP(H)-binding component (dIII) of transhydrogenase induced...