Document Detail

Multidrug-resistant recurrent breast cancer which responded to medroxyprogesterone acetate showing a remarkable improvement in the quality of life: report of a case and the role of team medical care.
MedLine Citation:
PMID:  9744415     Owner:  NLM     Status:  MEDLINE    
We herein report the case of a patient with recurrent breast cancer who showed a remarkable improvement in her quality of life (QOL) as a result of a good response to medroxyprogesterone acetate (MPA). A 43-year-old Japanese woman developed bone metastases 3 years after surgery. Subsequent radiotherapy and chemoendocrine therapy with CAF (cyclophosphamide, adriamycin, 5-fluorouracil) and tamoxifen all failed, and she could not sit up because of bone metastases. The performance status (PS) on admission was grade 4. After admission, delirium accompanied with sensory and visual hallucination caused by intense anxiety occurred, and a continuous consultation by psychiatrists was necessary. MPA treatment at the dose of 1200 mg/day alleviated the bone pain, thus improving her PS to grade 1. Her appetite also improved, while her mental state stabilized. A bone scintigram revealed an improvement of bone metastases, and the tumor markers also returned to normal values. The patient thus showed a pronounced improvement in her QOL due to both MPA treatment and team medical care. The role of the medical staff as well as the importance of their cooperation in achieving an improvement in the QOL of cancer patients is also discussed.
T Kurihara; Y Higashi; K Suemasu; T Tabei; S Ishiguro; Y Iino; Y Morishita; F Takeda
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Surgery today     Volume:  28     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-30     Completed Date:  1998-12-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  979-84     Citation Subset:  IM    
Breast Surgery Clinic, Saitama Cancer Center, Japan.
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MeSH Terms
Antineoplastic Agents, Hormonal / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols*
Bone Neoplasms / drug therapy,  secondary
Breast Neoplasms / drug therapy*
Carcinoma, Ductal, Breast / drug therapy*,  secondary
Chemotherapy, Adjuvant
Combined Modality Therapy
Cyclophosphamide / therapeutic use
Doxorubicin / therapeutic use
Drug Resistance, Multiple*
Drug Resistance, Neoplasm*
Fluorouracil / therapeutic use
Medroxyprogesterone Acetate / therapeutic use*
Neoplasm Recurrence, Local / drug therapy*
Palliative Care
Patient Care Team*
Quality of Life*
Reg. No./Substance:
0/Antineoplastic Agents, Hormonal; 0/CAF protocol; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 71-58-9/Medroxyprogesterone Acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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