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Multidrug-resistant TB in Zambia: review of national data from 2000 to 2011.
MedLine Citation:
PMID:  24033538     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) is posing a great threat to global TB control. The burden in Zambia is not well defined because routine surveillance data are scarce. We reviewed national MDR-TB data for the last decade to inform future public health policy with respect to MDR-TB in Zambia.
METHOD: Retrospective review of national surveillance of MDR-TB data, TB programme and laboratory reports between 2000 and 2011.
RESULTS: The total number of DSTs performed during this 11-year period was 2 038 and accounted for 2.6% (2 038/78 639) of all the retreatment cases notified. The total number of diagnosed MDR-TB cases for this period was 446, of which 56.3% (251/446) were male and 41.7% (186/446) female. Only one child was found to have MDR-TB. Poly-drug resistance accounted for 18.9% (172/911) of the DR-TB cases and 8.4% of the total DSTs. 8.8% (80/911) of the DR-TB cases showed either rifampicin mono- or poly-resistance other than MDR-TB. No XDR-TB was reported. There were no data available on DR-TB and HIV co-infection. Only 65 MDR-TB patients were notified and put on second-line treatment according to WHO guidelines.
CONCLUSIONS: Multidrug-resistant tuberculosis may be an emerging challenge in Zambia. There is a need to invest in improving the capacity of the TB programme to detect and manage MDR-TB.
Authors:
Nathan Kapata; Pascalina Chanda-Kapata; Matthew Bates; Peter Mwaba; Frank Cobelens; Martin P Grobusch; Alimuddin Zumla
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-9-11
Journal Detail:
Title:  Tropical medicine & international health : TM & IH     Volume:  -     ISSN:  1365-3156     ISO Abbreviation:  Trop. Med. Int. Health     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610576     Medline TA:  Trop Med Int Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 John Wiley & Sons Ltd.
Affiliation:
Ministry of Health, Lusaka, Zambia; National TB and Leprosy Control Programme, Ministry of Health, Lusaka, Zambia; University of Zambia-University College London Medical School Research and Training Programme, Lusaka, Zambia; Center for Tropical Medicine and Travel Medicine, University of Amsterdam, Amsterdam, The Netherlands.
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