Document Detail

Multidrug resistance in mucoepidermoid carcinoma of the parotid gland--immunohistochemical investigations of P-glycoprotein expression.
MedLine Citation:
PMID:  23350593     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: P-glycoprotein plays a functional role in promoting the efflux of drug metabolites in certain malignant tumors. With this understanding we immunohistochemically investigated the expression of P-glycoprotein in parotid mucoepidermoid carcinoma tissues and examined prognostic factors that contribute to the treatment of parotid cancer.
METHODS: Thirteen patients with mucoepidermoid carcinoma of the parotid gland were included. P-glycoprotein expression was immunohistochemically investigated by a modified avidin-biotin-peroxidase complex method using four different antibodies.
RESULTS: P-glycoprotein expression was observed in a higher percentage of patients with higher grade malignancy. The tumor size-related difference in P-glycoprotein expression was only significant for staining with one antibody, and no significant differences were observed with or without induction chemotherapy.
Tohru Furusaka; Clarence T Sasaki; Akira Matsuda; Yasuhiko Susaki; Hiroshi Matsuda; Minoru Ikeda
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Publication Detail:
Type:  Journal Article     Date:  2013-01-28
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  133     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-17     Completed Date:  2013-12-03     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  England    
Other Details:
Languages:  eng     Pagination:  552-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Antineoplastic Agents / therapeutic use
Carcinoma, Mucoepidermoid / metabolism*,  pathology*,  therapy
Cohort Studies
Drug Resistance, Multiple*
Middle Aged
Neoplasm Grading
Neoplasm Staging
P-Glycoprotein / metabolism*
Parotid Neoplasms / metabolism*,  pathology*,  therapy
Tumor Burden
Reg. No./Substance:
0/Antineoplastic Agents; 0/P-Glycoprotein

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