| Multidisciplinary treatment of giant invasive prolactinomas in paediatric age: long-term follow-up in two children. | |
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MedLine Citation:
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PMID: 20352234 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Invasive giant prolactinomas are rare tumours, still representing a therapeutic challenge due to their characteristics of invasiveness and variable clinical course. Giant prolactinomas in childhood are extremely rare. Only single case reports have been described in the literature. CASE PRESENTATION: We report on two children who presented a progressive visual deterioration. Magnetic resonance imaging showed extensive intra-suprasellar tumour invading the anterior skull base. The laboratory investigations detected markedly elevated prolactin levels. The patients were firstly started on dopamine agonist therapy with partial reduction in size of the tumours. The debulking of the residual lesions through a transsphenoidal approach was then performed in both patients, one of whom requiring a second surgical procedure for tumour regrowth. The complete shrinkage of the residual adenomas was achieved after the treatment with conventional radiotherapy, with a follow-up of 13 and 14 years, respectively. DISCUSSION: Multidisciplinary therapeutic approach for giant prolactinomas in paediatric patients can be an effective treatment; despite the invasiveness of these tumours, the efficacy of this combined treatment can reach a satisfactory control of the disease at long term, assuring a good quality of life as well. |
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Authors:
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Mario Francesco Fraioli; Federica Novegno; Elisabetta Catena; Chiara Fraioli; Laura Moschettoni |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-30 |
Journal Detail:
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Title: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery Volume: 26 ISSN: 1433-0350 ISO Abbreviation: Childs Nerv Syst Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-12 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8503227 Medline TA: Childs Nerv Syst Country: Germany |
Other Details:
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Languages: eng Pagination: 1233-7 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University of Rome Tor Vergata, Viale Oxford 81, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Combined Modality Therapy Humans Magnetic Resonance Imaging Male Pituitary Gland / pathology, surgery Pituitary Neoplasms / pathology, therapy* Prolactinoma / pathology, therapy* Treatment Outcome |
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