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MULTIDISCIPLINARY MANAGEMENT IN MERKEL CELL CARCINOMA.
MedLine Citation:
PMID:  23216365     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Herein, we describe our experience with the treatment of Merkel cell carcinoma (MCC) and review the literature regarding MCC treatment regimens. Nine patients underwent treatment due to stage I, II or III MCC. The median follow-up was 39 months. In 5 cases, tumors were excised with skin margins of >2 cm, and skin margins were <2 cm in 4 patients. Local adjuvant radiotherapy (RT) was given to 4 patients, while 3 patients underwent local lymphadenectomy (LAD). Local recurrence occurred in 4 patients who did not undergo RT (among them 3 with excision margins <2 cm) after a mean time of 9 months. Despite re-treatment 2 of those patients developed metastases. Recurrence-free survival after primary therapy was achieved: (a) in 3 patients with stage I and II MCC treated surgically with excision margins <2 cm combined with radiotherapy or wide excision >2 cm alone (b) in 2 patients with stage III MCC treated with wide excision and LAD combined with local and regional RT. A review of the literature supports the following recommendations: (a) Excision with adequate margins combined with RT. (b) LAD with regional radiotherapy in cases of lymph node involvement. (c) SLNB in patients without clinically suspicious lymph nodes.
Authors:
Rafal Matkowski; Ewelina Lata; Marcin Zietek; Agnieszka Halon; Jozef Forgacz; Bartlomiej Szynglarewicz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-10
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Oncology and Division of Oncological Surgery, Wroclaw Medical University , Plac Hirszfelda 12, 53 413 Wroclaw , Poland.
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