| Multidisciplinary cost-containment program promoting oral metronidazole for treatment of antibiotic-associated colitis. | |
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MedLine Citation:
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PMID: 3348224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A multidisciplinary cost-containment program for promoting oral metronidazole in place of oral vancomycin as initial therapy of antibiotic-associated colitis (AAC) is described. The pharmacy department and the division of infectious diseases implemented the program in two phases. In the first phase, a one-year retrospective drug-use review in patients with AAC treated with oral vancomycin was conducted to determine the average cost of therapy per treatment course. In the second phase, the use of oral metronidazole instead of oral vancomycin for initial treatment of AAC was promoted using inservice-education programs and distribution of pocket-size brochures containing AAC treatment guidelines to medical staff. The pharmacy and therapeutics committee supported the program by endorsing metronidazole as the drug of choice for AAC and by distributing follow-up progress reports of the program to medical staff. Pharmacists on the nursing units were responsible for enforcing the program stipulations regarding vancomycin and metronidazole use and for collecting data on patient-specific drug use. Six months after implementation of the program, the average cost of drug therapy for AAC had decreased by 89%, from $343.24 per patient to $37.50 per patient. The projected annual savings resulting from the program was $38,829.02. All prescribing physicians and dispensing pharmacists complied 100% with the program stipulations regarding drug use. The multidisciplinary program described here was successful in promoting the use of oral metronidazole for initial therapy of AAC. |
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Authors:
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L L Briceland; R Quintiliani; C H Nightingale |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of hospital pharmacy Volume: 45 ISSN: 0002-9289 ISO Abbreviation: Am J Hosp Pharm Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-04-15 Completed Date: 1988-04-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370474 Medline TA: Am J Hosp Pharm Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 122-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacy Practice, Albany College of Pharmacy, NY 12208. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anti-Bacterial Agents / adverse effects* Colitis / chemically induced, drug therapy*, economics Cost Control Humans Metronidazole / administration & dosage, therapeutic use* Pharmacists Pharmacy Service, Hospital / economics Pharmacy and Therapeutics Committee Vancomycin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 1404-90-6/Vancomycin; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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