Document Detail


A multidisciplinary approach to the treatment of anti-NMDA-receptor antibody encephalitis: a case and review of the literature.
MedLine Citation:
PMID:  22772674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anti-NMDAR (N-methyl-d-aspartate receptor) encephalitis is a novel autoimmune and paraneoplastic disease often presenting as acute psychosis. Few studies exist in the psychiatric literature on neuroimmunity and behavioral management. This article reviews the epidemiology, diagnosis, pathophysiology, and management of this disease from a neuropsychiatric perspective. Patients have potential for near-complete recovery with early diagnosis and intervention. In addition to immune-suppression and tumor removal, electroconvulsive therapy may be an important tool in treatment of the underlying process in cases developing life-threatening catatonia. Psychiatrists should be familiar with treatment options, since they may be consulted within the context of a multispecialty team.
Authors:
Andrea Mann; Nikolas Mata Machado; Ni Liu; Abdul-Hussein Mazin; Kenneth Silver; Khalid I Afzal
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  24     ISSN:  1545-7222     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2012  
Date Detail:
Created Date:  2012-07-09     Completed Date:  2012-11-13     Revised Date:  2012-12-04    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Neuroscience, University of Chicago Medical Center, Chicago, IL, USA. andrea.mann@uchospitals.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-N-Methyl-D-Aspartate Receptor Encephalitis* / diagnosis,  drug therapy,  epidemiology,  physiopathology,  surgery,  therapy
Disease Management*
Electroconvulsive Therapy / psychology
Female
Humans
Magnetic Resonance Imaging / psychology
Ovarian Neoplasms / surgery*
Patient Care Team / organization & administration*
Psychotropic Drugs / therapeutic use
Teratoma / surgery*
Chemical
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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