Document Detail

Multidirectional differentiation in neuroendocrine neoplasms.
MedLine Citation:
PMID:  6146648     Owner:  NLM     Status:  MEDLINE    
Histopathological and experimental observations indicate that tumors composed wholly or in part of neuroendocrine elements may arise in tissues derived from ectoderm (including neuroectoderm), mesoderm, and endoderm. These tumors frequently exhibit multidirectional differentiation as manifested by multihormonality and by the presence of morphological features indicative of divergent differentiation both in vivo and in vitro. The existence of stem cells, plasticity of differentiated cells, microenvironmental influences, and random events are factors which might all interact to determine the characteristics of any particular tumor. The production of characteristic regulatory peptide products in association with tumors of specific histological subtypes and with other neuroendocrine markers suggests mechanisms for nonrandom activation of multiple genes common to neuroendocrine-programmed cells. Future studies applying new molecular biological techniques to intact tissues and to in vitro models may help to clarify the mechanisms that regulate the expression of the neuroendocrine phenotype in normal and neoplastic states.
R A DeLellis; A S Tischler; H J Wolfe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  32     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-30     Completed Date:  1984-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  899-904     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / secretion
Apudoma / pathology*
Calcitonin / secretion
Carcinoid Tumor / pathology
Gastrins / secretion
Hormones, Ectopic / secretion
Neurotensin / secretion
Ovarian Neoplasms / pathology
Pancreatic Neoplasms / pathology,  secretion
Pheochromocytoma / secretion
Somatostatin / secretion
Thyroid Neoplasms / secretion
Uterine Neoplasms / pathology
Vasoactive Intestinal Peptide / secretion
Grant Support
Reg. No./Substance:
0/Gastrins; 0/Hormones, Ectopic; 37221-79-7/Vasoactive Intestinal Peptide; 39379-15-2/Neurotensin; 51110-01-1/Somatostatin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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