Document Detail


Multidirectional differentiation in neuroendocrine neoplasms.
MedLine Citation:
PMID:  6146648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Histopathological and experimental observations indicate that tumors composed wholly or in part of neuroendocrine elements may arise in tissues derived from ectoderm (including neuroectoderm), mesoderm, and endoderm. These tumors frequently exhibit multidirectional differentiation as manifested by multihormonality and by the presence of morphological features indicative of divergent differentiation both in vivo and in vitro. The existence of stem cells, plasticity of differentiated cells, microenvironmental influences, and random events are factors which might all interact to determine the characteristics of any particular tumor. The production of characteristic regulatory peptide products in association with tumors of specific histological subtypes and with other neuroendocrine markers suggests mechanisms for nonrandom activation of multiple genes common to neuroendocrine-programmed cells. Future studies applying new molecular biological techniques to intact tissues and to in vitro models may help to clarify the mechanisms that regulate the expression of the neuroendocrine phenotype in normal and neoplastic states.
Authors:
R A DeLellis; A S Tischler; H J Wolfe
Related Documents :
9252858 - Primary biliary cirrhosis and gastric carcinoid: a rare association?
6187428 - The neuroendocrine products of intestinal carcinoids. an immunoperoxidase study of 35 c...
9840098 - Tryptophan hydroxylase antibodies used in the diagnosis of carcinoid.
9287968 - The multiple endocrine neoplasia type i gene locus is involved in the pathogenesis of t...
11558618 - Cytotoxic alkaloids and a flavan from the bulbs of crinum asiaticum var. japonicum.
2979828 - Antitumor effect of 24r,25-dihydroxyvitamin d3.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society     Volume:  32     ISSN:  0022-1554     ISO Abbreviation:  J. Histochem. Cytochem.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-08-30     Completed Date:  1984-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815334     Medline TA:  J Histochem Cytochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  899-904     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Gland Neoplasms / secretion
Animals
Apudoma / pathology*
Calcitonin / secretion
Carcinoid Tumor / pathology
Cricetinae
Female
Gastrins / secretion
Hormones, Ectopic / secretion
Humans
Neurotensin / secretion
Ovarian Neoplasms / pathology
Pancreatic Neoplasms / pathology,  secretion
Pheochromocytoma / secretion
Rats
Somatostatin / secretion
Thyroid Neoplasms / secretion
Uterine Neoplasms / pathology
Vasoactive Intestinal Peptide / secretion
Grant Support
ID/Acronym/Agency:
CA 17389/CA/NCI NIH HHS; CA 27808/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins; 0/Hormones, Ectopic; 37221-79-7/Vasoactive Intestinal Peptide; 39379-15-2/Neurotensin; 51110-01-1/Somatostatin; 9007-12-9/Calcitonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of benzodiazepines in primary-care geriatric patients.
Next Document:  Nephropathia epidemica in Norway: antigen and antibodies in rodent reservoirs and antibodies in sele...