| Multidetector Computed Tomography Follow-up of Hypoattenuating Small Liver Lesions in Patients With Rectal Cancer. | |
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MedLine Citation:
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PMID: 20686401 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: : To study the behavior of hypoattenuating liver lesions, deemed too small to characterize at baseline scanning with multidetector computed tomography (CT), in patients with rectal cancer. METHODS: : Retrospective review of locally advanced rectal cancer patients from a radiation oncology therapy database was conducted. Patients who presented before neoadjuvant chemoradiation without metastases at baseline CT and with follow-up scans for at least 1 year after therapy were evaluated. CT studies were reviewed for the presence and change in size of hypoattenuating liver lesions (<15 mm) at baseline and follow-up. RESULTS: : A total of 616 consecutive patients from the radiotherapy database were reviewed. Of these, 70 patients with a total of 163 hepatic lesions met the selection criteria. The mean patient age was 62.4 years (range, 26-85 years). All patients subsequently underwent surgery and adjuvant chemotherapy. The mean time of radiographic imaging from baseline CT to most recent surveillance CT was 3.3 years (range, 1.1-7.4 years). Two radiologists independently reviewed the CTs. The lesions were stable in 56 of 70 (80.0%, 95% confidence interval: 69%, 89%) patients. Of 163 lesions, 148 (90.8%) were stable, 8 (4.9%) regressed, and 7 (4.3%) progressed in size. No significant difference in results was found for patients stratified according to T-stage (P = 0.41) and N-stage (P > 0.99). CONCLUSION: : In patients with rectal cancer, majority of small hypoattenuating liver lesions remain stable and are treated as benign lesions, at multidetector CT follow-up of more than a year. Nevertheless, hepatic lesion stability during systemic therapy should still be interpreted with caution and closely followed for at least 1 year after completion of therapy. |
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Authors:
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Cher Heng Tan; Priya R Bhosale; Prajnan Das; Christopher H Crane; Chitra Viswanathan; Bharat Raval; Cathy Eng; Revathy B Iyer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical oncology Volume: 34 ISSN: 1537-453X ISO Abbreviation: Am. J. Clin. Oncol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207754 Medline TA: Am J Clin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 411-6 Citation Subset: IM |
Affiliation:
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From the Departments of *Diagnostic Radiology, †Radiation Oncology Treatment, and ‡GI Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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