Document Detail

Multidetector CT Measurement of Myocardial Extracellular Volume in Acute Patchy and Contiguous Infarction: Validation with Microscopic Measurement.
MedLine Citation:
PMID:  25247406     Owner:  NLM     Status:  Publisher    
Purpose To provide proof of concept that expansion of myocardial extracellular volume ( MECV myocardial ECV ), measured at contrast material-enhanced multidetector computed tomography (CT), can be used as a (a) marker for viability based on histologic confirmation and (b) predictor of severity of myocardial injury. Materials and Methods Animals cared for in compliance with Institutional Animal Care and Use Committee served as controls (group 1, n = 6) or were subjected to microinfarction by using 16-mm(3) (60 000 count) microemboli (group 2) and 32-mm(3) (120 000 count) microemboli (group 3), contiguous infarct with left anterior descending artery ( LAD left anterior descending coronary artery ) occlusion followed by reperfusion (group 4), or the combination of LAD left anterior descending coronary artery occlusion and 32-mm(3) microemboli followed by reperfusion (group 5) (n = 7 per group). MECV myocardial ECV calculations were based on regional measurements of signal attenuation at contrast-enhanced multidetector CT and counterstaining of infarct at microscopy. Two-way analysis of variance and Student t tests were used to determine significant differences (P < .05). Data were presented as means ± standard deviations. Results Mean signal attenuation at equilibrium state of contrast media distribution (10 minutes) was significantly different among blood (137 HU ± 10), myocardial muscle (77 HU ± 12, P < .05), and skeletal muscle (35 HU ± 12, P < .05). Patchy microinfarct, contiguous infarct, and microinfarct with preexisting contiguous infarct can be differentiated on the basis of mean MECV myocardial ECV (24% ± 3 [group 1] vs 36% ± 3 [group 2], P < .01, and 55% ± 5 [group 4], 56% ± 4 [group 5] vs 41% ± 3 [group 3], P < .05). Microscopy measurements confirmed multidetector CT quantitative measurements and differences in patterns of infarct caused by obstruction of major and minor coronary arteries. Regression analysis revealed excellent correlation between regional MECV myocardial ECV using multidetector CT and microscopy (r(2) = 0.92). Conclusion Contrast-enhanced multidetector CT is a suitable noninvasive imaging technique for assessing MECV myocardial ECV in acute patchy and contiguous infarct caused by obstruction of major and minor coronary vessels. © RSNA, 2014.
Robert Jablonowski; Mark W Wilson; Loi Do; Steven W Hetts; Maythem Saeed
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-22
Journal Detail:
Title:  Radiology     Volume:  -     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-23     Completed Date:  -     Revised Date:  2014-9-24    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  140131     Citation Subset:  -    
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