Document Detail

"Multicystic dysplastic kidney (Potter type II syndrome) and agenesis of corpus callosum (ACC) in two consecutive pregnancies: a possible teratogenic effect of electromagnetic exposure in utero".
MedLine Citation:
PMID:  19065324     Owner:  NLM     Status:  MEDLINE    
Agenesis of the corpus callosum is found in about 5 per 1,000 births and it is due to maldevelopment or, secondary, to destructive lesions. Multicystic dysplastic kidneys is a consequence of either developmental failure of the mesonephric blastema to form nephrons or to early urinary obstruction due to urethral or ureteric atresia and can be found in about 1 per 1,000 live births. A case of fetal multicystic dysplastic kidney disease (Potter type II syndrome) and complete agenesis of the corpus callosum demonstrated by the presence of Probst bundles associated with colpocephaly occurring in the same mother in her two consecutive pregnancies is reported. Data regarding possible teratogenetic effect due to electromagnetic exposure in utero have also been investigated and raised suspicionus as a potential risk factor. In cases of suspected second trimester ultrasound diagnosis of agenesis of corpus callosum (ACC), the following clinical management should be recommended: fetal karyotype; a second level scan with differentiation between underlying conditions such as hydrocephalus and holoprosencephaly; antenatal MRI to enhance the diagnostic accuracy of possible associated neuronal migration (when possible); and direct demonstration of the presence of the Probst bundles to neurohistology.
Gabriele Tonni; Daniela Azzoni; Alessandro Ventura; Fabrizio Ambrosetti; Claudio De Felice
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal and pediatric pathology     Volume:  27     ISSN:  1551-3823     ISO Abbreviation:  Fetal Pediatr Pathol     Publication Date:  2008  
Date Detail:
Created Date:  2008-12-09     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230972     Medline TA:  Fetal Pediatr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-73     Citation Subset:  IM    
Prenatal Diagnostic Service, Division of Obstetrics and Gynecology, Guastalla Provincial Hospital-AUSL Reggio Emilia, Reggio Emilia, Italy.
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MeSH Terms
Abnormalities, Multiple* / etiology,  pathology
Corpus Callosum* / abnormalities,  radiation effects
Maternal Exposure
Multicystic Dysplastic Kidney* / etiology,  pathology
Prenatal Diagnosis
Reg. No./Substance:

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