Document Detail

Multicomponent methods: evaluation of new and traditional soft tissue mineral models by in vivo neutron activation analysis.
MedLine Citation:
PMID:  12399267     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Practical and accurate methods for quantifying the soft tissue mineral component of multicomponent fat-estimation models are needed. OBJECTIVES: The aims were to develop a new complete model for estimating soft tissue minerals based on measured total body water (TBW) and extracellular water (ECW) and a simplified new model based on TBW measurements only and to compare these estimates with those determined with 2 traditional models (ie, the Brozek and Selinger models) and with criterion estimates based on in vivo neutron activation (IVNA) analysis. DESIGN: The subjects were 156 healthy adults and 50 patients with AIDS. Total body potassium, sodium, chlorine, and calcium were measured by IVNA; TBW by (3)H(2)O or D(2)O dilution; ECW by bromide dilution; and bone mineral by dual-energy X-ray absorptiometry. RESULTS: The mean (+/- SD) mass of total-body soft tissue minerals in healthy adults was 467 +/- 62 g with the IVNA model, 492 +/- 62 g with the new model, and 487 +/- 59 g with the simplified new model. Compared with the IVNA model, the complete and simplified new models overestimated soft tissue minerals by 5.4% and 4.6% (both P < 0.001), respectively. In contrast, the Brozek and Selinger models overestimated overall mean soft tissue minerals by 35% and 99% (both P < 0.001), respectively. Overall results for soft tissue mineral prediction with the 2 new models were less satisfactory for the patients with AIDS, although the results were better than those with the traditional models. CONCLUSIONS: The physiologically formulated complete new model for estimating soft tissue minerals provides the opportunity to upgrade the accuracy of current multicomponent models for estimating total body fat.
ZiMian Wang; F Xavier Pi-Sunyer; Donald P Kotler; Lucian Wielopolski; Robert T Withers; Richard N Pierson; Steven B Heymsfield
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  76     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-25     Completed Date:  2002-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  968-74     Citation Subset:  AIM; IM    
Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA.
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MeSH Terms
Acquired Immunodeficiency Syndrome / metabolism
Body Composition*
Body Water / chemistry
Extracellular Space / chemistry
Intracellular Fluid / chemistry
Middle Aged
Minerals / analysis*
Models, Biological*
Neutron Activation Analysis*
Reference Values
Grant Support
42618//PHS HHS
Reg. No./Substance:

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