| Multicomponent methods: evaluation of new and traditional soft tissue mineral models by in vivo neutron activation analysis. | |
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MedLine Citation:
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PMID: 12399267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Practical and accurate methods for quantifying the soft tissue mineral component of multicomponent fat-estimation models are needed. OBJECTIVES: The aims were to develop a new complete model for estimating soft tissue minerals based on measured total body water (TBW) and extracellular water (ECW) and a simplified new model based on TBW measurements only and to compare these estimates with those determined with 2 traditional models (ie, the Brozek and Selinger models) and with criterion estimates based on in vivo neutron activation (IVNA) analysis. DESIGN: The subjects were 156 healthy adults and 50 patients with AIDS. Total body potassium, sodium, chlorine, and calcium were measured by IVNA; TBW by (3)H(2)O or D(2)O dilution; ECW by bromide dilution; and bone mineral by dual-energy X-ray absorptiometry. RESULTS: The mean (+/- SD) mass of total-body soft tissue minerals in healthy adults was 467 +/- 62 g with the IVNA model, 492 +/- 62 g with the new model, and 487 +/- 59 g with the simplified new model. Compared with the IVNA model, the complete and simplified new models overestimated soft tissue minerals by 5.4% and 4.6% (both P < 0.001), respectively. In contrast, the Brozek and Selinger models overestimated overall mean soft tissue minerals by 35% and 99% (both P < 0.001), respectively. Overall results for soft tissue mineral prediction with the 2 new models were less satisfactory for the patients with AIDS, although the results were better than those with the traditional models. CONCLUSIONS: The physiologically formulated complete new model for estimating soft tissue minerals provides the opportunity to upgrade the accuracy of current multicomponent models for estimating total body fat. |
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Authors:
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ZiMian Wang; F Xavier Pi-Sunyer; Donald P Kotler; Lucian Wielopolski; Robert T Withers; Richard N Pierson; Steven B Heymsfield |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 76 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-25 Completed Date: 2002-11-27 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 968-74 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, Columbia University, College of Physicians and Surgeons, New York, NY, USA. zw28@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acquired Immunodeficiency Syndrome
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metabolism Adult Body Composition* Body Water / chemistry Extracellular Space / chemistry Humans Intracellular Fluid / chemistry Middle Aged Minerals / analysis* Models, Biological* Neutron Activation Analysis* Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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42618//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Minerals |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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