Document Detail

Multicomponent cleaning verification of stainless steel surfaces for the removal of dairy residues using infrared microspectroscopy.
MedLine Citation:
PMID:  21535750     Owner:  NLM     Status:  MEDLINE    
PRACTICAL APPLICATION: We report the application of Fourier transform infrared microspectroscopy (FTIR) for the validation of CIP cleaning efficiency that would provide a basis for better understanding of the mechanisms involved in the removal of physical soil and food residues from different types of equipment surfaces commonly utilized in the biotech, pharmaceutical, and food industries. Reliable calibration models were generated that showed the ability to predict the amounts of dairy soils on the surface of stainless steel coupons. Including a swabbing step of the coupons before infrared spectral acquisition provided improved sensitivity and reproducibility for multicomponent cleaning verification. Results from this research project would allow designing experiments to rapidly evaluate different materials and finishes, the effects of process variables, the influence of food components, and the development of reliable and robust cleaning validation protocols to ensure the safety and quality of the product.
Matthew P Lang; Nurdan A Kocaoglu-Vurma; W James Harper; Luis E Rodriguez-Saona
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Journal of food science     Volume:  76     ISSN:  1750-3841     ISO Abbreviation:  J. Food Sci.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-05-03     Completed Date:  2011-08-18     Revised Date:  2014-11-13    
Medline Journal Info:
Nlm Unique ID:  0014052     Medline TA:  J Food Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  C303-8     Citation Subset:  IM    
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MeSH Terms
Dairy Products*
Equipment Contamination*
Food-Processing Industry
Least-Squares Analysis
Multivariate Analysis
Spectroscopy, Fourier Transform Infrared / methods*
Stainless Steel*
Reg. No./Substance:
12597-68-1/Stainless Steel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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