Document Detail

Multicompartmental analysis of late contrast enhancement in areas of myocardial infarction supplied by chronically occluded coronary arteries.
MedLine Citation:
PMID:  19097090     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To analyze the relationship between late contrast enhancement (LCE) and the interstitial distribution volume (V(In)) of gadolinium (Gd) tracers in the myocardial infarction (MI) areas supplied by chronically occluded arteries from patients. In animal experimental models, LCE has already been shown to correspond to an enhanced V(In) of Gd tracers and thus, to a decrease in the amount of intact cells. MATERIALS AND METHODS: A multicompartmental analysis was applied to serial MRI images encompassing both infarct and remote areas and recorded with a conventional two-dimensional (2D) segmented inversion-recovery gradient-echo (IR-GRE) sequence during a 15-minute period following Gd-diethylenetriamine pentaacetic acid (Gd-DTPA) injection in 12 patients with Q-wave MI supplied by chronically occluded coronary arteries. RESULTS: V(In) from infarct tissue was: 1) higher than V(In) from remote areas (in % of myocardial volume: 74 +/- 16% vs. 20 +/- 7%, P < 0.001); and 2) correlated with the quantification of LCE between infarct and noninfarct areas at the 15th minute (R(2) = 0.63, P = 0.002). However, the difference in V(In) between infarct and remote myocardium was a much better correlate of this quantified LCE (R(2) = 0.85, P < 0.001). CONCLUSION: Detection of LCE in the MI territories supplied by chronically occluded arteries relates to the difference in the V(In) of tracers between the infarct and the noninfarct areas.
Damien Mandry; Françoise Lapicque; Freddy Odille; Wassila Djaballah; Andrei Codreanu; Jean-Marie Escanyé; Jacques Felblinger; Gilles Karcher; Michel Claudon; Pierre-Yves Marie
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  29     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-85     Citation Subset:  IM    
INSERM, ERI13 Imagerie Adaptative Diagnostique et Interventionnelle, Nancy, France.
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MeSH Terms
Chronic Disease
Computer Simulation
Contrast Media
Coronary Occlusion / complications*,  diagnosis*
Gadolinium DTPA / diagnostic use*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Magnetic Resonance Imaging, Cine / methods*
Middle Aged
Models, Cardiovascular
Myocardial Infarction / diagnosis*,  etiology*
Reproducibility of Results
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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