Document Detail

Multicentric reticulohistiocytosis associated with liver carcinoma: report of a case.
MedLine Citation:
PMID:  22949898     Owner:  NLM     Status:  PubMed-not-MEDLINE    
We report a unique case of multicentric reticulohistiocytosis (MRH) associated with liver carcinoma. A 61-year-old man presented with a 4-month history of nonpruritic, generalized, ruby-red papules and nodules, accompanied by fever, joint swelling and difficulty in swallowing. Skin histology showed polymorphic histiocyte infiltration with typical 'ground glass' cytoplasm. Further immunohistochemical studies characterized the lesions as positive for leukocyte common antigen, HLA-DR and CD68. The patient had a history of hepatitis B, and systemic examination, including carcinoma index and type-B ultrasonic examination, revealed high levels of AFP and a solid tumor, which was considered malignant, localized on the right lobe of the liver. Treatment of the liver carcinoma resulted in a significant improvement of the skin symptoms. This is the first case study to report an association between MRH and liver carcinoma. A review of the English-language literature reveals the close linkage between MRH and malignancy. All patients with MRH should be evaluated and monitored carefully to determine the underlying neoplasm.
Ling Han; Qiong Huang; Kang-Huang Liao; Lian-Jun Chen; Wen-Yi Kong; Wen-Wen Fu; Jing-Hua Xu
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Publication Detail:
Type:  Journal Article     Date:  2012-08-01
Journal Detail:
Title:  Case reports in dermatology     Volume:  4     ISSN:  1662-6567     ISO Abbreviation:  Case Rep Dermatol     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-09-05     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101517685     Medline TA:  Case Rep Dermatol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  -    
Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, PR China.
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