Document Detail

Multicentric mast cell tumors in a horse.
MedLine Citation:
PMID:  20412546     Owner:  NLM     Status:  MEDLINE    
A 6-year-old female Rocky Mountain horse was presented for evaluation of draining tracts and distal limb subcutaneous edema on the left front and left hind limbs that had been present for 2 weeks. Direct smears of fluid collected by fine-needle aspiration of subcutaneous fluid from both limbs were highly cellular with a predominance of eosinophils accompanied by numerous, moderately atypical, variably granulated mast cells. The cytologic diagnosis was mast cell tumor (MCT) with prominent eosinophilic infiltration with a differential diagnosis of eosinophilic granuloma. Histologic evaluation of surgical biopsies of lesions from both limbs was performed on sections stained with H&E, toluidine blue, and Luna stains. The histologic diagnosis was MCT, and staining with toluidine blue and Luna stains confirmed the presence of mast cells and eosinophils, respectively. In addition, the mast cells strongly expressed CD117. This is the first reported case of cutaneous mast cell neoplasia in a horse in which primary presenting complaints were draining tracts and distal limb subcutaneous edema involving multiple limbs. This case illustrates the utility of staining for CD117 expression in combination with traditional stains, such as toluidine blue and Luna, in differentiating MCTs from other eosinophilic lesions in horses.
Laurie M Millward; Alex Hamberg; Jennifer Mathews; Cecilia Machado-Parrula; Christopher Premanandan; Samuel D A Hurcombe; M Judith Radin; Maxey L Wellman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary clinical pathology / American Society for Veterinary Clinical Pathology     Volume:  39     ISSN:  1939-165X     ISO Abbreviation:  Vet Clin Pathol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-03-11     Revised Date:  2012-10-04    
Medline Journal Info:
Nlm Unique ID:  9880575     Medline TA:  Vet Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  365-70     Citation Subset:  IM    
Copyright Information:
©2010 American Society for Veterinary Clinical Pathology.
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Diagnosis, Differential
Eosinophilia / pathology,  veterinary
Extremities / pathology
Horse Diseases / diagnosis,  pathology*
Mast Cells / pathology
Mastocytosis, Cutaneous / diagnosis,  pathology,  veterinary*
Skin / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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