Document Detail


Multicentre double blind clinical trial on ranitidine for gastroduodenal ulcer.
MedLine Citation:
PMID:  6115807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study was carried out in 168 patients treated in 5 Departments of Gastroenterology according to a standardized design. All were diagnosed and followed-up by panendoscopy: they were give similar diet and antacids ad libitum, and were urged not to smoke. Such basic therapy in our studies resulted in 30-40% of gastric, and about 50% of duodenal ulcers coded packages of the tested drug. Tablets contained wither 150 mg of Ranitidine or placebo They were taken twice a day. Spontaneous healing under such conditions occurred in the present study in 37% of gastric, and 45% of duodenal, ulcers, while in patients taking Ranitidine 62% of gastric (P less than 0.05) and 82% of duodenal ulcers (p less than 0.01) were cicatrized after 3 weeks. There were no drop-outs, and no undesired effects were observed.
Authors:
K Gibinski; A Nowak; A Gabryelewicz; W Szalaj; J Hasik; H Klincewicz; J Pokora; P Radwan; P Kosecki; J Pachlewski
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  28     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  216-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Clinical Trials as Topic
Double-Blind Method
Duodenal Ulcer / drug therapy*
Female
Furans / therapeutic use*
Histamine H2 Antagonists / therapeutic use*
Humans
Male
Middle Aged
Ranitidine
Stomach Ulcer / drug therapy*
Chemical
Reg. No./Substance:
0/Furans; 0/Histamine H2 Antagonists; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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