| Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. | |
| | |
MedLine Citation:
|
PMID: 20043800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the effect of food containing high concentrations of fish oil omega-3 fatty acids and a low omega-6-omega-3 fatty acid ratio on clinical signs of osteoarthritis in dogs. DESIGN: Randomized, double-blinded, controlled clinical trial. ANIMALS: 127 client-owned dogs with osteoarthritis in 1 or more joints from 18 privately owned veterinary clinics. PROCEDURES: Dogs were randomly assigned to be fed for 6 months with a typical commercial food or a test food containing a 31-fold increase in total omega-3 fatty acid content and a 34-fold decrease in omega-6-omega-3 ratio, compared with the control food. Dog owners completed a questionnaire about their dog's arthritic condition, and investigators performed a physical examination and collected samples for a CBC and serum biochemical analyses (including measurement of fatty acids concentration) at the onset of the study and at 6, 12, and 24 weeks afterward. RESULTS: Dogs fed the test food had a significantly higher serum concentration of total omega-3 fatty acids and a significantly lower serum concentration of arachidonic acid at 6, 12, and 24 weeks. According to owners, dogs fed the test food had a significantly improved ability to rise from a resting position and play at 6 weeks and improved ability to walk at 12 and 24 weeks, compared with control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Ingestion of the test food raised blood concentrations of omega-3 fatty acids and appeared to improve the arthritic condition in pet dogs with osteoarthritis. |
| | |
Authors:
|
James K Roush; Chadwick E Dodd; Dale A Fritsch; Timothy A Allen; Dennis E Jewell; William D Schoenherr; Daniel C Richardson; Phillip S Leventhal; Kevin A Hahn |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American Veterinary Medical Association Volume: 236 ISSN: 0003-1488 ISO Abbreviation: J. Am. Vet. Med. Assoc. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-01 Completed Date: 2010-02-23 Revised Date: 2010-06-14 |
Medline Journal Info:
|
Nlm Unique ID: 7503067 Medline TA: J Am Vet Med Assoc Country: United States |
Other Details:
|
Languages: eng Pagination: 59-66 Citation Subset: IM |
Affiliation:
|
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Nutritional Physiological Phenomena
/
physiology* Animals Dog Diseases / blood, diet therapy*, pathology Dogs Dose-Response Relationship, Drug Double-Blind Method Fatty Acids, Omega-3 / administration & dosage*, blood, therapeutic use Fatty Acids, Omega-6 / administration & dosage, blood Female Fish Oils* / administration & dosage, chemistry Food, Fortified Male Osteoarthritis / blood, diet therapy, pathology, veterinary* Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils |
| Comments/Corrections | |
Erratum In:
|
J Am Vet Med Assoc. 2010 Jun 1;236(11):1191 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of changes in number of doses and anatomic location for administration of an Escherichia coli...
Next Document: Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bea...