Document Detail

Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs.
MedLine Citation:
PMID:  20043800     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the effect of food containing high concentrations of fish oil omega-3 fatty acids and a low omega-6-omega-3 fatty acid ratio on clinical signs of osteoarthritis in dogs. DESIGN: Randomized, double-blinded, controlled clinical trial. ANIMALS: 127 client-owned dogs with osteoarthritis in 1 or more joints from 18 privately owned veterinary clinics. PROCEDURES: Dogs were randomly assigned to be fed for 6 months with a typical commercial food or a test food containing a 31-fold increase in total omega-3 fatty acid content and a 34-fold decrease in omega-6-omega-3 ratio, compared with the control food. Dog owners completed a questionnaire about their dog's arthritic condition, and investigators performed a physical examination and collected samples for a CBC and serum biochemical analyses (including measurement of fatty acids concentration) at the onset of the study and at 6, 12, and 24 weeks afterward. RESULTS: Dogs fed the test food had a significantly higher serum concentration of total omega-3 fatty acids and a significantly lower serum concentration of arachidonic acid at 6, 12, and 24 weeks. According to owners, dogs fed the test food had a significantly improved ability to rise from a resting position and play at 6 weeks and improved ability to walk at 12 and 24 weeks, compared with control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Ingestion of the test food raised blood concentrations of omega-3 fatty acids and appeared to improve the arthritic condition in pet dogs with osteoarthritis.
James K Roush; Chadwick E Dodd; Dale A Fritsch; Timothy A Allen; Dennis E Jewell; William D Schoenherr; Daniel C Richardson; Phillip S Leventhal; Kevin A Hahn
Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Veterinary Medical Association     Volume:  236     ISSN:  0003-1488     ISO Abbreviation:  J. Am. Vet. Med. Assoc.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-01     Completed Date:  2010-02-23     Revised Date:  2010-06-14    
Medline Journal Info:
Nlm Unique ID:  7503067     Medline TA:  J Am Vet Med Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
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MeSH Terms
Animal Nutritional Physiological Phenomena / physiology*
Dog Diseases / blood,  diet therapy*,  pathology
Dose-Response Relationship, Drug
Double-Blind Method
Fatty Acids, Omega-3 / administration & dosage*,  blood,  therapeutic use
Fatty Acids, Omega-6 / administration & dosage,  blood
Fish Oils* / administration & dosage,  chemistry
Food, Fortified
Osteoarthritis / blood,  diet therapy,  pathology,  veterinary*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fish Oils
Erratum In:
J Am Vet Med Assoc. 2010 Jun 1;236(11):1191

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