Document Detail

Multicenter trial of cryotherapy for retinopathy of prematurity. 3 1/2-year outcome--structure and function. Cryotherapy for Retinopathy of Prematurity Cooperative Group.
MedLine Citation:
PMID:  8447743     Owner:  NLM     Status:  MEDLINE    
Cryotherapy for Retinopathy of Prematurity Cooperative Group Reports from the 3- and 12-month follow-up examinations in the Multicenter Cryotherapy for Retinopathy of Prematurity trial indicated a beneficial effect of cryotherapy in the treatment of severe retinopathy of prematurity. This report provides results from the 3 1/2-year follow-up examination on 92% of the 256 survivors from the original cohort of 291 infants in the randomized trial. Functional outcome was evaluated by masked assessment of letter acuity using the HOTV crowded letter test and grating acuity using the Teller Acuity Card procedure. Structural outcome was evaluated by physician's assessment of retinopathy of prematurity residua in the posterior pole. All three outcome measures showed a reduction in unfavorable outcomes in treated vs control eyes: 46.6% vs 57.5% (P < .01) for letter acuity, 52.4% vs 65.6% (P < .001) for grating acuity, and 26.1% vs 45.4% (P < .001) for posterior pole status. These results support the long-term efficacy and safety of cryotherapy in the treatment of severe retinopathy of prematurity.
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  111     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-04-05     Completed Date:  1993-04-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  339-44     Citation Subset:  AIM; IM    
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MeSH Terms
Follow-Up Studies
Gestational Age
Infant, Newborn
Postoperative Complications
Retinopathy of Prematurity / physiopathology*,  surgery*
Treatment Outcome
Visual Acuity*
Grant Support
5 U10 EY05874/EY/NEI NIH HHS
Comment In:
Arch Ophthalmol. 1994 Feb;112(2):156   [PMID:  8141907 ]
Arch Ophthalmol. 1993 Mar;111(3):319-20   [PMID:  8447737 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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