Document Detail


Multicenter trial of cadexomer iodine to treat venous stasis ulcer.
MedLine Citation:
PMID:  2669345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a crossover study designed to judge the efficacy of the topical polymeric starch iodophore, cadexomer iodine, in accelerating the healing of venous stasis ulcers, 75 patients were prospectively randomly assigned to receive either cadexomer iodine or standard treatment. The control treatment consisted of a standard saline wet-to-dry compressive dressing. The patients improved with either treatment: ulcers healed more than twice as rapidly using cadexomer iodine (n = 38) as with standard therapy (n = 37) (P = .0025). Ulcers treated with cadexomer iodine showed trends toward less pain, exudate, pus, and debris, and a more rapid development of granulation tissue. Twelve patients crossed over from control treatment to the use of cadexomer iodine because of a failure to heal, but no patients switched to control therapy from the use of cadexomer iodine (P = .01). Except for occasional mild local burning in wounds treated with cadexomer iodine, no adverse effects were noted with either regimen.
Authors:
G A Holloway; K H Johansen; R W Barnes; G E Pierce
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Western journal of medicine     Volume:  151     ISSN:  0093-0415     ISO Abbreviation:  West. J. Med.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-08     Completed Date:  1989-09-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410504     Medline TA:  West J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Female
Humans
Iodine / therapeutic use*
Iodine Compounds*
Iodophors
Male
Microspheres
Middle Aged
Multicenter Studies as Topic
Prospective Studies
Random Allocation
Varicose Ulcer
Chemical
Reg. No./Substance:
0/Iodine Compounds; 0/Iodophors; 7553-56-2/Iodine; 94820-09-4/cadexomer iodine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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