Document Detail

Multicenter phase II study of antimicrobial prophylaxis in low-risk patients undergoing distal gastrectomy for gastric cancer.
MedLine Citation:
PMID:  16557434     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In Japan, antimicrobial prophylaxis (AMP) is typically administered for 3 to 4 days postoperatively for clean-contaminated operations such as distal gastrectomy. This far exceeds the recommended 2h or less laid out by the Centers for Disease Control (CDC) guidelines for the prevention of surgical-site infections (SSIs), after a clean-contaminated operation. METHODS: Patients with gastric cancer, which was curable by distal gastrectomy with D2 lymphandectomy, were assigned to a multicenter phase II study. One gram of cefazolin within 3 min of the first surgical incision and intraoperative supplements of g of cefazolin every h were administered. AMP was not administered after skin closure unless postoperative infection occurred. The occurrence of SSIs was monitored until postoperative day 30 as the primary endpoint of this study. RESULTS: In 56 patients, three SSIs (5.4%) and one remote site infection (1.8%) developed. No other postoperative infections were observed. CONCLUSION: Our data indicate that the CDC guidelines regarding AMP may also be sufficient for patients undergoing clean-contaminated operations in Japan.
Hiroshi Imamura; Hiroshi Furukawa; Shohei Iijima; Seichi Sugihara; Toshimasa Tsujinaka; Hideaki Tsukuma; Toshio Shimokawa
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Publication Detail:
Type:  Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association     Volume:  9     ISSN:  1436-3291     ISO Abbreviation:  Gastric Cancer     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-24     Completed Date:  2006-06-13     Revised Date:  2007-01-08    
Medline Journal Info:
Nlm Unique ID:  100886238     Medline TA:  Gastric Cancer     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  32-5     Citation Subset:  IM    
Department of Surgery, Sakai City Hospital,, Sakai, Osaka, 590-0064, Japan.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use*
Antibiotic Prophylaxis*
Cefazolin / therapeutic use*
Middle Aged
Risk Factors
Stomach Neoplasms / surgery*
Surgical Wound Infection / prevention & control*
Reg. No./Substance:
0/Anti-Bacterial Agents; 25953-19-9/Cefazolin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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