| Multicenter phase II study of antimicrobial prophylaxis in low-risk patients undergoing distal gastrectomy for gastric cancer. | |
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MedLine Citation:
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PMID: 16557434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In Japan, antimicrobial prophylaxis (AMP) is typically administered for 3 to 4 days postoperatively for clean-contaminated operations such as distal gastrectomy. This far exceeds the recommended 2h or less laid out by the Centers for Disease Control (CDC) guidelines for the prevention of surgical-site infections (SSIs), after a clean-contaminated operation. METHODS: Patients with gastric cancer, which was curable by distal gastrectomy with D2 lymphandectomy, were assigned to a multicenter phase II study. One gram of cefazolin within 3 min of the first surgical incision and intraoperative supplements of g of cefazolin every h were administered. AMP was not administered after skin closure unless postoperative infection occurred. The occurrence of SSIs was monitored until postoperative day 30 as the primary endpoint of this study. RESULTS: In 56 patients, three SSIs (5.4%) and one remote site infection (1.8%) developed. No other postoperative infections were observed. CONCLUSION: Our data indicate that the CDC guidelines regarding AMP may also be sufficient for patients undergoing clean-contaminated operations in Japan. |
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Authors:
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Hiroshi Imamura; Hiroshi Furukawa; Shohei Iijima; Seichi Sugihara; Toshimasa Tsujinaka; Hideaki Tsukuma; Toshio Shimokawa |
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Publication Detail:
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Type: Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Volume: 9 ISSN: 1436-3291 ISO Abbreviation: Gastric Cancer Publication Date: 2006 |
Date Detail:
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Created Date: 2006-03-24 Completed Date: 2006-06-13 Revised Date: 2007-01-08 |
Medline Journal Info:
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Nlm Unique ID: 100886238 Medline TA: Gastric Cancer Country: Japan |
Other Details:
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Languages: eng Pagination: 32-5 Citation Subset: IM |
Affiliation:
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Department of Surgery, Sakai City Hospital,, Sakai, Osaka, 590-0064, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents
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therapeutic use* Antibiotic Prophylaxis* Cefazolin / therapeutic use* Female Gastrectomy* Humans Male Middle Aged Risk Factors Stomach Neoplasms / surgery* Surgical Wound Infection / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 25953-19-9/Cefazolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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