Document Detail

Multicenter, comparative study of cefotaxime and ceftriaxone for treatment of uncomplicated gonorrhea.
MedLine Citation:
PMID:  8235924     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: Cefotaxime is a third-generation cephalosporin that has in vitro activity against Neisseria gonorrhoeae, including beta-lactamase-producing strains. A single 1-g intramuscular dose is effective and is recommended by the Centers for Disease Control and Prevention as an alternative treatment for uncomplicated gonorrhea. GOAL OF THIS STUDY: This study was conducted to evaluate the efficacy and safety of a lower 500-mg dose of cefotaxime in the treatment of uncomplicated gonococcal infections. STUDY DESIGN: In a randomized multicenter study, patients who had uncomplicated gonorrhea were treated with 500 mg of cefotaxime or 250 mg of ceftriaxone. Both antibiotics were given intramuscularly. Efficacy and safety were assessed four to seven days following treatment. RESULTS: Six hundred thirteen patients were enrolled. Bacteriologic eradication rates for anogenital infection were 97.7% of the patients (213/218) in the cefotaxime group and 99.1% of the patients (221/223) in the ceftriaxone group (P = 0.243). Adverse events occurred in 4.2% and 7.5% of patients in the two groups, respectively. CONCLUSION: Cefotaxime 500 mg appears to be a safe and cost-effective alternative to ceftriaxone 250 mg for the treatment of uncomplicated gonorrhea.
W M McCormack; W J Mogabgab; R B Jones; E W Hook; G D Wendel; H H Handsfield
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Sexually transmitted diseases     Volume:  20     ISSN:  0148-5717     ISO Abbreviation:  Sex Transm Dis     Publication Date:    1993 Sep-Oct
Date Detail:
Created Date:  1993-12-01     Completed Date:  1993-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7705941     Medline TA:  Sex Transm Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
State University of New York, Health Science Center, Brooklyn 11203.
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MeSH Terms
Cefotaxime / adverse effects,  pharmacology,  therapeutic use*
Ceftriaxone / adverse effects,  pharmacology,  therapeutic use*
Gonorrhea / drug therapy*
Injections, Intramuscular
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects*
Penicillins / pharmacology
Tetracycline / pharmacology
Treatment Outcome
Reg. No./Substance:
0/Penicillins; 60-54-8/Tetracycline; 63527-52-6/Cefotaxime; 73384-59-5/Ceftriaxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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