| Multicenter clinical trial of thrombolytic therapy in 1,406 patients with acute myocardial infarction. Collaborative Group of Clinical Trial for Urokinase Therapy. | |
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MedLine Citation:
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PMID: 9772414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the clinical efficacy and safety of intravenous thrombolytic therapy of Urokinase Tech-Pool (UKTP) in acute myocardial infarction (AMI). METHODS: The data were collected from the 148 participating hospitals from November, 1994 to April, 1996. A total of 1,406 patients with AMI were analyzed to evaluate the clinical efficacy, side effects and mortality of UKTP. The patency of the infarct-related artery (IRA) was evaluated in 124 patients by coronary artery angiography (CAG) 90 minutes after the onset of UKTP infusion. RESULTS: The reperfusion rate in IRA was 73.5% by clinical standards. The patency rate was 72.6% by CAG. The total mortality during the first 5 weeks was 7.8% (109/1,406). The rate of minor bleeding was 10.2% (143/1,406), of major bleeding 0.43% (6/1,406) and of intracranial hemorrhage 0.50% (7/1,406). In elderly patients (> 75 years old), UKTP was as effective and safe as in younger patients (< 65 years old). Late thrombolytic therapy with UKTP (> 6 hours after the onset of symptom) was still effective. The appropriate dosage of UKTP might be 150 million units of infusion within 30 minutes. CONCLUSION: UKTP is an effective, reliable and safe agent in the thrombolytic therapy of AMI. |
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Authors:
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D Hu; Z Xu |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase II; Journal Article; Multicenter Study |
Journal Detail:
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Title: Chinese medical journal Volume: 110 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-10-27 Completed Date: 1998-10-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: CHINA |
Other Details:
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Languages: eng Pagination: 839-42 Citation Subset: IM |
Affiliation:
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Heart Center, Beijing Red Cross Chaoyang Hospital, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Female Humans Male Middle Aged Myocardial Infarction / drug therapy*, mortality Thrombolytic Therapy* Time Factors Urokinase-Type Plasminogen Activator / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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