Document Detail

Multiallergen nasal challenges in nonallergic rhinitis.
MedLine Citation:
PMID:  18592815     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been proposed that some patients with nonallergic rhinitis may have "localized allergy" of the nasal mucosa. Nasal challenges with aeroallergens can help determine whether a patient is clinically allergic via an IgE-mediated pathway.
OBJECTIVE: To determine the prevalence of localized allergy in patients with negative skin prick test results via nasal challenges with an array of allergens.
METHODS: Twenty individuals with perennial rhinitis and negative epicutaneous test results to common perennial aeroallergens underwent nasal challenges to glycerin, Alternaria, cockroach, timothy grass, cat hair, and Dermatophagoides pteronyssinus. Total symptom scores, peak nasal inspiratory flow rates, and nasal eosinophil counts were determined.
RESULTS: Of 20 patients with nonallergic rhinitis, 4 were hyperresponsive to glycerin and were not subsequently challenged. Eleven patients had negative nasal challenges. Five patients developed positive challenges (total symptom score > or = 5) to 7 allergens. These 5 patients returned for nasal provocation testing to their offending allergens, and these repeated challenges were negative. Three control subjects with allergic rhinitis developed positive challenges after nasal allergen challenge.
CONCLUSIONS: Although some individuals with nonallergic rhinitis can have positive nasal allergen challenges, these results were not reproducible in the present patient population.
Dania A Wierzbicki; Amee R Majmundar; Diane E Schull; David A Khan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  100     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-08-18     Revised Date:  2011-01-14    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-7     Citation Subset:  IM    
Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8859, USA.
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MeSH Terms
Allergens / administration & dosage,  immunology
Alternaria / chemistry,  immunology
Antigens, Dermatophagoides / administration & dosage,  immunology
Cell Count
Cockroaches / chemistry,  immunology
Eosinophils / pathology
Hypersensitivity / diagnosis,  immunology
Middle Aged
Nasal Mucosa / immunology
Nasal Provocation Tests*
Nose / pathology,  physiopathology
Phleum / chemistry,  immunology
Rhinitis / diagnosis*,  immunology*
Skin Tests
Reg. No./Substance:
0/Allergens; 0/Antigens, Dermatophagoides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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