| MultiHance in the dynamic phase of contrast enhancement: a pictorial assessment. | |
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MedLine Citation:
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PMID: 10608399 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present article demonstrates pictorially the use of MultiHance (gadobenate dimeglumine, Gd-BOPTA) in dynamic magnetic resonance imaging and is aimed at ensuring that the product is not misconceived as solely a hepatobiliary agent for use in delayed, static magnetic resonance imaging for the improved detection of focal liver lesions. The enhancement patterns of three malignant (hepatocellular carcinoma, cholangiocarcinoma and metastasis) and three benign (hemangioma, focal nodular hyperplasia and adenoma) lesion types are demonstrated. Each was imaged during the dynamic phase of contrast enhancement immediately following the intravenous bolus administration of 0.05 mmol/kg MultiHance. The article demonstrates that the enhancement patterns observed for these relatively common lesions are similar to those reported in the literature after the intravenous bolus administration of conventional, non-specific 'extracellular fluid' contrast agents, and concludes by inferring that MultiHance behaves in the liver as a conventional gadolinium-based agent in the first minutes after administration. |
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Authors:
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L Grazioli; M Kirchin; G Pirovano; A Spinazzi |
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Publication Detail:
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Type: Clinical Trial; Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of computer assisted tomography Volume: 23 Suppl 1 ISSN: 0363-8715 ISO Abbreviation: J Comput Assist Tomogr Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2000-01-05 Completed Date: 2000-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703942 Medline TA: J Comput Assist Tomogr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S61-4 Citation Subset: IM |
Affiliation:
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Medical and Regulatory Affairs, Bracco SpA, Milano, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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diagnosis Bile Duct Neoplasms / diagnosis Bile Ducts, Intrahepatic / pathology Carcinoma, Hepatocellular / diagnosis Cholangiocarcinoma Contrast Media* Diagnosis, Differential Focal Nodular Hyperplasia / diagnosis Gadolinium / diagnostic use* Hemangioma / diagnosis Humans Injections, Intravenous Liver Diseases / diagnosis* Liver Neoplasms / diagnosis Magnetic Resonance Imaging / methods* Meglumine / administration & dosage, analogs & derivatives*, diagnostic use Organometallic Compounds / administration & dosage, diagnostic use* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 113662-23-0/gadobenic acid; 6284-40-8/Meglumine; 7440-54-2/Gadolinium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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