| Multi-stability in Platelets and their response to Gold Nanoparticles. | |
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MedLine Citation:
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PMID: 21310267 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The nanoparticle response of platelets is shown to be critically dependent on extent of pre-activation of platelets by agonist like ADP. A transition from de-aggregatory to aggregatory state is triggered in presence of gold nanoparticles (AuNP) only in such critical conditions. Adhered and suspended platelets respond differentially to nanoparticles. Pre-activation in the adhered state induced by shear forces explain such observation. The nanoparticle effect is associated with enhanced release reaction, tyrosine phosphorylation and CD62P expression level. Unlike cancer cells, whose response is maximal when nanoparticle size is optimal (within the range 50-70nm), the platelet response monotonically increases with lowering of AuNP size. Uptake study, using quenching of Quinacrine hydrochloride fluorescence by AuNP, clearly indicates that accumulation 18nm AuNP is several fold higher than the 68nm AuNP. It is further shown that AuNP response can provide a simple measure for thrombotic risk associated with nano-drugs. |
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Authors:
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Suryyani Deb; Hirak K Patra; Prabir Lahiri; Anjan Kr Dasgupta; Kuntal Chakrabarti; Utpal Chaudhuri |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-7 |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: - ISSN: 1549-9642 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Biochemistry, University of Calcutta , Kolkata 700019. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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