Document Detail

Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation.
MedLine Citation:
PMID:  20047939     Owner:  NLM     Status:  MEDLINE    
Cells and tissues undergo complex physical processes during cryopreservation. Understanding the underlying physical phenomena is critical to improve current cryopreservation methods and to develop new techniques. Here, we describe multi-scale approaches for modelling cell and tissue cryopreservation including heat transfer at macroscale level, crystallization, cell volume change and mass transport across cell membranes at microscale level. These multi-scale approaches allow us to study cell and tissue cryopreservation.
Feng Xu; Sangjun Moon; Xiaohui Zhang; Lei Shao; Young Seok Song; Utkan Demirci
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Philosophical transactions. Series A, Mathematical, physical, and engineering sciences     Volume:  368     ISSN:  1364-503X     ISO Abbreviation:  Philos Trans A Math Phys Eng Sci     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-05     Completed Date:  2010-04-02     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101133385     Medline TA:  Philos Trans A Math Phys Eng Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-83     Citation Subset:  IM    
Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Center for Bioengineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Body Temperature / physiology*
Cell Physiological Phenomena*
Computer Simulation
Energy Transfer / physiology*
Models, Biological*
Thermal Conductivity
Grant Support

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