| Multi-photon resonance enhancement of third harmonic generation in human oxyhemoglobin and deoxyhemoglobin. | |
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MedLine Citation:
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PMID: 20583034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cancer cells require excessive oxygen and nutrition to support their rapid growth, so angiogenesis and decrease of blood oxygen are often associated with areas of cancer development. Current technologies for blood oxygen measurement, however, do not possess high spatial resolution and therefore cannot be used to detect small tumors in their early stage. In this paper, we studied the third harmonic generation (THG) spectra of oxy- and deoxyhemoglobin in the 1170-1365 nm region, which is strongly influenced by the multi-photon resonance effect, especially around the Soret transition band. Our spectroscopic results thus indicate the high potential of THG spectroscopic microscopy for oxygen depletion level measurement of a single red blood cell in vivo. |
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Authors:
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Chieh-Feng Chang; Che-Hang Yu; Chi-Kuang Sun |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biophotonics Volume: 3 ISSN: 1864-0648 ISO Abbreviation: J Biophotonics Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318567 Medline TA: J Biophotonics Country: Germany |
Other Details:
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Languages: eng Pagination: 678-85 Citation Subset: IM |
Affiliation:
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Department of Electrical Engineering and Graduate Institute of Photonics and Optoelectronics, National Taiwan University, Taipei 10617, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Hemoglobins / metabolism* Humans Oxygen / blood, metabolism Oxyhemoglobins / metabolism* Photons* Spectrum Analysis / methods* |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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