Document Detail

Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES).
MedLine Citation:
PMID:  11878748     Owner:  NLM     Status:  MEDLINE    
Autopsy tissue samples from the brain front lobe, cerebellum, heart, kidney (cortex and medulla), liver, pancreas, spleen and ovary were analysed for AL, B, Ba, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, Sr and Zn in 30 (17 women and 13 men) subjects ranging in age from 17 to 96 years at Haukeland University Hospital in Norway. The tissues were selected from macroscopically normal organs and samples were handled according to guidelines recommended to avoid contamination in the pre-analytical phase. Concentration of the trace elements were determined by the inductively coupled plasma atomic emission spectrometry technique (ICP-AES). In most tissues the concentrations of the essential trace elements followed the order Fe> Zn> Cu> Mn> Se> Cr> Co except in the ovary where Se was higher than Mn. The liver was the major site of deposition for Co, Cu and Mn as well as the spleen for Co, brain front lobe for Cu and pancreas for Mn. Ba, Sr and Ni built up in the ovary foLLowed by the kidney. Older subjects accumulated Ba and Sr in most tissues, whereas Al accumulated in the kidney cortex and Cd in the brain cerebellum. Generally males had higher concentrations of trace elements in the different tissue sampLes than females with the exception of Mn in the brain front lobe and heart and Sr in the liver. ICP-AES is a useful method to assess the concentration and the profiLe of trace elements in human autopsy tissues.
Reem Rahil-Khazen; Bjørn J Bolann; Andreas Myking; Rune J Ulvik
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  16     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-06     Completed Date:  2002-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  15-25     Citation Subset:  IM    
Institute of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Aged, 80 and over
Cerebellum / chemistry
Chromium / analysis
Cobalt / analysis
Copper / analysis
Frontal Lobe / chemistry
Iron / analysis
Kidney / chemistry
Liver / chemistry
Manganese / analysis
Middle Aged
Myocardium / chemistry
Ovary / chemistry
Pancreas / chemistry
Postmortem Changes
Quality Control
Selenium / analysis
Sex Characteristics
Spectrophotometry / methods*
Spleen / chemistry
Time Factors
Trace Elements / analysis*
Zinc / analysis
Reg. No./Substance:
0/Trace Elements; 7439-89-6/Iron; 7439-96-5/Manganese; 7440-47-3/Chromium; 7440-48-4/Cobalt; 7440-50-8/Copper; 7440-66-6/Zinc; 7782-49-2/Selenium

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