Document Detail

Multi-drug resistance genes in the management of neoplastic disease.
MedLine Citation:
PMID:  1682490     Owner:  NLM     Status:  MEDLINE    
P-gp can function as an ATP-dependent cytotoxic drug-efflux pump. In normal tissues, protein expression is localized to cell surfaces that face excretory lumina; hence, P-gp may function as a toxic-waste disposal system. Tumors that are derived from these tissues can be high expressors of P-gp, and these tumors tend to display intrinsic chemoresistance. Other non-expressing tumors can become P-gp positive after treatment or at relapse, suggesting that mdr may be involved in acquired resistance. The use of MDR-modifying agents has had some clinical success, and further trials of chemosensitizers are proceeding. P-gp overexpression does not explain how clinical resistance to anthracyclines, alkylating agents, and cis-platinum can arise simultaneously. In these cases, multiple genetic mechanisms of resistance may coexist. Eventually, mdr status can be used to select the most effective chemotherapy protocol for the individual. Currently, conversion of a previously mdr negative tumor to mdr expression, in the face of clinical resistance, justifies changing to a non-MDR drug protocol, or if not feasible, the use of MDR sensitizers.
J Stewart; N T Gorman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary internal medicine / American College of Veterinary Internal Medicine     Volume:  5     ISSN:  0891-6640     ISO Abbreviation:  J. Vet. Intern. Med.     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1991-12-17     Completed Date:  1991-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8708660     Medline TA:  J Vet Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-47     Citation Subset:  IM    
Department of Veterinary Surgery, Glasgow University Veterinary School, Bearsden.
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MeSH Terms
Drug Resistance / genetics*
Gene Expression Regulation, Neoplastic
Membrane Glycoproteins / biosynthesis,  genetics
Neoplasm Proteins / biosynthesis,  genetics
Neoplasms / drug therapy*,  genetics
Neoplasms, Experimental / drug therapy*,  genetics
Tumor Cells, Cultured
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Neoplasm Proteins; 0/P-Glycoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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