Document Detail


Multidetector CT features of pulmonary focal ground-glass opacity: differences between benign and malignant.
MedLine Citation:
PMID:  22128130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate different features between benign and malignant pulmonary focal ground-glass opacity (fGGO) on multidetector CT (MDCT).
METHODS: 82 pathologically or clinically confirmed fGGOs were retrospectively analysed with regard to demographic data, lesion size and location, attenuation value and MDCT features including shape, margin, interface, internal characteristics and adjacent structure. Differences between benign and malignant fGGOs were analysed using a χ(2) test, Fisher's exact test or Mann-Whitney U-test. Morphological characteristics were analysed by binary logistic regression analysis to estimate the likelihood of malignancy.
RESULTS: There were 21 benign and 61 malignant lesions. No statistical differences were found between benign and malignant fGGOs in terms of demographic data, size, location and attenuation value. The frequency of lobulation (p=0.000), spiculation (p=0.008), spine-like process (p=0.004), well-defined but coarse interface (p=0.000), bronchus cut-off (p=0.003), other air-containing space (p=0.000), pleural indentation (p=0.000) and vascular convergence (p=0.006) was significantly higher in malignant fGGOs than that in benign fGGOs. Binary logistic regression analysis showed that lobulation, interface and pleural indentation were important indicators for malignant diagnosis of fGGO, with the corresponding odds ratios of 8.122, 3.139 and 9.076, respectively. In addition, a well-defined but coarse interface was the most important indicator of malignancy among all interface types. With all three important indicators considered, the diagnostic sensitivity, specificity and accuracy were 93.4%, 66.7% and 86.6%, respectively.
CONCLUSION: An fGGO with lobulation, a well-defined but coarse interface and pleural indentation gives a greater than average likelihood of being malignant.
Authors:
L Fan; S-Y Liu; Q-C Li; H Yu; X-S Xiao
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-29
Journal Detail:
Title:  The British journal of radiology     Volume:  85     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-29     Completed Date:  2012-09-12     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  897-904     Citation Subset:  AIM; IM    
Affiliation:
Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cohort Studies
Diagnosis, Differential
Female
Focal Infection / pathology,  radiography
Humans
Immunohistochemistry
Likelihood Functions
Logistic Models
Lung / pathology*,  radiography*
Lung Diseases / pathology,  radiography
Lung Neoplasms / pathology,  radiography*
Male
Middle Aged
Multidetector Computed Tomography / methods*
Multivariate Analysis
Retrospective Studies
Sensitivity and Specificity
Solitary Pulmonary Nodule / pathology,  radiography*
Statistics, Nonparametric
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