| Multidetector CT features of pulmonary focal ground-glass opacity: differences between benign and malignant. | |
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MedLine Citation:
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PMID: 22128130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate different features between benign and malignant pulmonary focal ground-glass opacity (fGGO) on multidetector CT (MDCT). METHODS: 82 pathologically or clinically confirmed fGGOs were retrospectively analysed with regard to demographic data, lesion size and location, attenuation value and MDCT features including shape, margin, interface, internal characteristics and adjacent structure. Differences between benign and malignant fGGOs were analysed using a χ(2) test, Fisher's exact test or Mann-Whitney U-test. Morphological characteristics were analysed by binary logistic regression analysis to estimate the likelihood of malignancy. RESULTS: There were 21 benign and 61 malignant lesions. No statistical differences were found between benign and malignant fGGOs in terms of demographic data, size, location and attenuation value. The frequency of lobulation (p=0.000), spiculation (p=0.008), spine-like process (p=0.004), well-defined but coarse interface (p=0.000), bronchus cut-off (p=0.003), other air-containing space (p=0.000), pleural indentation (p=0.000) and vascular convergence (p=0.006) was significantly higher in malignant fGGOs than that in benign fGGOs. Binary logistic regression analysis showed that lobulation, interface and pleural indentation were important indicators for malignant diagnosis of fGGO, with the corresponding odds ratios of 8.122, 3.139 and 9.076, respectively. In addition, a well-defined but coarse interface was the most important indicator of malignancy among all interface types. With all three important indicators considered, the diagnostic sensitivity, specificity and accuracy were 93.4%, 66.7% and 86.6%, respectively. CONCLUSION: An fGGO with lobulation, a well-defined but coarse interface and pleural indentation gives a greater than average likelihood of being malignant. |
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Authors:
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L Fan; S-Y Liu; Q-C Li; H Yu; X-S Xiao |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2011-11-29 |
Journal Detail:
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Title: The British journal of radiology Volume: 85 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-06-29 Completed Date: 2012-09-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 897-904 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Changzheng Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Diagnosis, Differential Female Focal Infection / pathology, radiography Humans Immunohistochemistry Likelihood Functions Logistic Models Lung / pathology*, radiography* Lung Diseases / pathology, radiography Lung Neoplasms / pathology, radiography* Male Middle Aged Multidetector Computed Tomography / methods* Multivariate Analysis Retrospective Studies Sensitivity and Specificity Solitary Pulmonary Nodule / pathology, radiography* Statistics, Nonparametric |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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