| Multi-component extracellular matrices based on peptide self-assembly. | |
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MedLine Citation:
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PMID: 20603663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracellular matrices (ECMs) are challenging design targets for materials synthesis because they serve multiple biological roles, and they are composed of multiple molecular constituents. In addition, their composition and activities are dynamic and variable between tissues, and they are difficult to study mechanistically in physiological contexts. Nevertheless, the design of synthetic ECMs is a central consideration in applications such as regenerative medicine and 3D cell culture. In order to produce synthetic matrices having both multi-component construction and high levels of compositional definition, strategies based on molecular self-assembly are receiving increasing interest. These approaches are described in this tutorial review and compared with the structures and processes in native ECMs that serve as their inspiration. |
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Authors:
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Joel H Collier; Jai S Rudra; Joshua Z Gasiorowski; Jangwook P Jung |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2010-07-05 |
Journal Detail:
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Title: Chemical Society reviews Volume: 39 ISSN: 1460-4744 ISO Abbreviation: Chem Soc Rev Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-11-30 Revised Date: 2012-03-13 |
Medline Journal Info:
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Nlm Unique ID: 0335405 Medline TA: Chem Soc Rev Country: England |
Other Details:
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Languages: eng Pagination: 3413-24 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Chicago, 5841 S. Maryland Ave., MC 5032, Chicago, IL 60637, USA. collier@uchicago.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Extracellular Matrix / chemistry* Humans Peptide Fragments / chemistry*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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1R01EB009701/EB/NIBIB NIH HHS; 7R21EB007335/EB/NIBIB NIH HHS; R01 EB009701-04/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Peptide Fragments |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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