| Multi-centre first-trimester screening for Down syndrome in the Netherlands in routine clinical practice. | |
| | |
MedLine Citation:
|
PMID: 16752435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: This is the first report on the results of a first-trimester combined-test screening programme in the Netherlands in a multi-centre routine clinical setting. METHODS: Between July 2002 and May 2004, blood samples were taken from subjects in 44 centres in the Netherlands and sent to our laboratory to assay for maternal serum concentrations of fbeta-hCG and PAPP-A. Fetal nuchal translucency (NT) was measured in the participating centres at a gestational age (GA) of 10-14 weeks. Results of those pregnancies for which a combined biochemical and NT risk was calculated were included in the epidemiological analysis of this study. RESULTS: A total of 4033 singleton pregnancies were included in the analysis. The median maternal age of the analysed group was 36.5 years. The distribution of GA was biphasic, with median GA of 10.3 and 12.1 weeks, respectively. The detection rate using the combined ultrasound and serum screening at a cut-off level of 1 in 250 was 71% (15/21), with a screen-positive rate of 4.7%. CONCLUSION: The results of this study show that the first-trimester combined test is suitable as a prenatal screening test in a multi-centre routine clinical setting in the Netherlands. Strict performance evaluation should identify weaknesses in the organisation that impair the performance of the test. Here, the performance of NT was especially identified as a candidate for improvement. |
| | |
Authors:
|
P C J I Schielen; M van Leeuwen-Spruijt; I Belmouden; L H Elvers; M Jonker; J G Loeber |
Related Documents
:
|
1768345 - Routine examination by ultrasound for the detection of fetal malformations in a low ris... 12042255 - Chlamydia trachomatis in subfertile women undergoing uterine instrumentation. how we ca... 16615415 - Construct and ecological validity of the occupational therapy adult perceptual screenin... 11898925 - Barriers to dietary control among pregnant women with phenylketonuria--united states, 1... 23273755 - Midluteal serum progesterone concentration does not predict the outcome of pregnancy in... 10632425 - Where does the embryo implant after embryo transfer in humans? |
Publication Detail:
|
Type: Journal Article; Multicenter Study |
Journal Detail:
|
Title: Prenatal diagnosis Volume: 26 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-28 Completed Date: 2006-12-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
|
Languages: eng Pagination: 711-8 Citation Subset: IM |
Affiliation:
|
Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Peter.Schielen@rivm.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Chorionic Gonadotropin, beta Subunit, Human / blood Down Syndrome / blood, diagnosis*, epidemiology Female Humans Middle Aged Netherlands / epidemiology Nuchal Translucency Measurement* / standards Pregnancy Pregnancy Trimester, First* Pregnancy-Associated Plasma Protein-A / analysis Quality Assurance, Health Care |
| Chemical | |
Reg. No./Substance:
|
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal Marfan syndrome: report of one case and review of the literature.
Next Document: Carrier diagnostics and prevention of hemoglobinopathies in early pregnancy in The Netherlands: a pi...