Document Detail


Multi-centre assessment of mycotic rhinosinusitis in dogs: a retrospective study of initial treatment success (1998 to 2008).
MedLine Citation:
PMID:  20536689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To retrospectively review the first treatment response of dogs with mycotic rhinosinusitis to commonly utilised treatment techniques. METHODS: Medical records of dogs treated for mycotic rhinosinusitis were obtained retrospectively via a manual review of the clinical databases of six veterinary referral centres for the period of January 1998 to June 2008, and first treatment outcome was evaluated. Historical and clinicopathological findings were also reviewed to evaluate their impact on treatment success or failure. RESULTS: There was no significant difference in first treatment outcome between treatment groups (P=0.21). When all topical treatments were considered together (n=85), 39 dogs (45.8%) had a successful first treatment. Initial treatment success was associated with a younger age (56.3 versus 75.8 months; P=0.02) and was 2.7 times more likely in dogs with unilateral disease, although this was not significant (P=0.07). Adjunctive therapy with systemic antifungal agents was associated with treatment failure (P< or =0.01). Fifty-nine dogs (69.4%) responded successfully following multiple treatments. CLINICAL SIGNIFICANCE: Treatment of mycotic rhinosinusitis remains challenging, and multiple treatments are frequently required for adequate treatment. Reasons for first treatment failure are likely multifactorial in origin, making it difficult to predict those dogs that are likely to have a superior prognosis, regardless of the treatment type used.
Authors:
M Sharman; A Paul; D Davies; B MacKay; G Swinney; V Barrs; A Arteaga; I D Robertson; C Mansfield
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  The Journal of small animal practice     Volume:  51     ISSN:  1748-5827     ISO Abbreviation:  J Small Anim Pract     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-10-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0165053     Medline TA:  J Small Anim Pract     Country:  England    
Other Details:
Languages:  eng     Pagination:  423-7     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Antifungal Agents / therapeutic use*
Dog Diseases / drug therapy*
Dogs
Drug Therapy, Combination
Female
Male
Mycoses / drug therapy,  veterinary*
Retrospective Studies
Rhinitis / drug therapy,  veterinary*
Sinusitis / drug therapy,  veterinary*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antifungal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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