Document Detail

Multi-Ethnic Study of Atherosclerosis: Association between Left Atrial Function Using Tissue Tracking from Cine MR Imaging and Myocardial Fibrosis.
MedLine Citation:
PMID:  25019562     Owner:  NLM     Status:  Publisher    
Purpose To investigate the association between left atrial (LA) function and left ventricular myocardial fibrosis using cardiac magnetic resonance (MR) imaging in a multi-ethnic population. Materials and Methods For this HIPAA-compliant study, the institutional review board at each participating center approved the study protocol, and all participants provided informed consent. Of 2839 participants who had undergone cardiac MR in 2010-2012, 143 participants with myocardial scar determined with late gadolinium enhancement and 286 age-, sex-, and ethnicity-matched control participants were identified. LA volume, strain, and strain rate were analyzed by using multimodality tissue tracking from cine MR imaging. T1 mapping was applied to assess diffuse myocardial fibrosis. The association between LA parameters and myocardial fibrosis was evaluated with the Student t test and multivariable regression analysis. Results The scar group had significantly higher minimum LA volume than the control group (mean, 22.0 ± 10.5 [standard deviation] vs 19.0 ± 7.8, P = .002) and lower LA ejection fraction (45.9 ± 10.7 vs 51.3 ± 8.7, P < .001), maximal LA strain (Smax) (25.4 ± 10.7 vs 30.6 ± 10.6, P < .001) and maximum LA strain rate (SRmax) (1.08 ± 0.45 vs 1.29 ± 0.51, P < .001), and lower absolute LA strain rate at early diastolic peak (SRE) (-0.77 ± 0.42 vs -1.01 ± 0.48, P < .001) and LA strain rate at atrial contraction peak (SRA) (-1.50 ± 0.62 vs -1.78 ± 0.69, P < .001) than the control group. T1 time 12 minutes after contrast material injection was significantly associated with Smax (β coefficient = 0.043, P = .013), SRmax (β coefficient = 0.0025, P = .001), SRE (β coefficient = -0.0016, P = .027), and SRA (β coefficient -0.0028, P = .01) in the regression model. T1 time 25 minutes after contrast material injection was significantly associated with SRmax (β coefficient = 0.0019, P = .016) and SRA (β coefficient = -0.0022, P = .034). Conclusion Reduced LA regional and global function are related to both replacement and diffuse myocardial fibrosis processes. Clinical trial registration no. NCT00005487 © RSNA, 2014 Online supplemental material is available for this article.
Masamichi Imai; Bharath Ambale Venkatesh; Sanaz Samiei; Sirisha Donekal; Mohammadali Habibi; Anderson C Armstrong; Susan R Heckbert; Colin O Wu; David A Bluemke; João A C Lima
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-14
Journal Detail:
Title:  Radiology     Volume:  -     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  131971     Citation Subset:  -    
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