Document Detail


Muller's ratchet and the pattern of variation at a neutral locus.
MedLine Citation:
PMID:  12072478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function of the deleterious mutation rate, the fitness effects of the mutations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious mutations: a model where all deleterious mutations have equal effects and a model where there are two classes of deleterious mutations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.
Authors:
Isabel Gordo; Arcadio Navarro; Brian Charlesworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genetics     Volume:  161     ISSN:  0016-6731     ISO Abbreviation:  Genetics     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-19     Completed Date:  2003-01-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0374636     Medline TA:  Genetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835-48     Citation Subset:  IM    
Affiliation:
Instituto Gulbenkian da Ciência, P-2781-901 Oeiras, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Evolution
Genetic Variation*
Models, Genetic*
Monte Carlo Method
Mutation
Selection, Genetic
Comments/Corrections

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